ArticleCell reports2013
Multiple enhancers regulate Hoxd genes and the Hotdog LncRNA during cecum budding.
Article in Cell reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 69 citations in OpenAlex.
- Genome-Wide Annotation of Promoter-Enhancer Interactions via Chromatin Loops in the Hybrid Rat Diversity Panel.bioRxiv : the preprint server for biology · 2026Article
- TheBiomolecules · 2025Review
- Shared retinoic acid responsive enhancers coordinately regulate nascent transcription of Hoxb coding and non-coding RNAs in the developing mouse neural tube.Development (Cambridge, England) · 2023Article
- Genetic cold cases: lessons from solving complex congenital limb disorders.Genes & development · 2023Review
- Developmental and evolutionary comparative analysis of a regulatory landscape in mouse and chicken.Development (Cambridge, England) · 2022Article
- Transcriptional Regulation and Implications for ControllingJournal of developmental biology · 2022Review
- Induction of a chromatin boundary in vivo upon insertion of a TAD border.PLoS genetics · 2021Article
- Chromatin topology and the timing of enhancer function at theProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Mammalian-specific ectodermal enhancers control the expression ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- HOX gene cluster (de)regulation in brain: from neurodevelopment to malignant glial tumours.Cellular and molecular life sciences : CMLS · 2020Review
- Oral Administration of Penicillin or Streptomycin May Alter Serum Serotonin Level and Intestinal Motility via Different Mechanisms.Frontiers in physiology · 2020Article
- Comprehensive epigenome characterization reveals diverse transcriptional regulation across human vascular endothelial cells.Epigenetics & chromatin · 2019Article
- Impact of genome architecture on the functional activation and repression of Hox regulatory landscapes.BMC biology · 2019Article
- The constrained architecture of mammalianProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Paralogous HOX13 Genes in Human Cancers.Cancers · 2019Review
- A novel long non-coding RNA, lncKBTBD10, involved in bovine skeletal muscle myogenesis.In vitro cellular & developmental biology. Animal · 2019Article
- Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci.Genome biology · 2018Article
- TheGenes & development · 2017Article
- Control of growth and gut maturation byProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Embryonic timing, axial stem cells, chromatin dynamics, and the Hox clock.Genes & development · 2017Review
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a gene desert flanking the HoxD cluster. The start site of two opposite long noncoding RNAs (lncRNAs), Hotdog and Twin of Hotdog, selectively contacts the expressed Hoxd genes in the framework of a topological domain, coinciding with robust transcription of these genes during cecum budding. Both lncRNAs are specifically transcribed in the cecum, albeit bearing no detectable function in trans. Hedgehogs have kept this regulatory potential despite the absence of the cecum, suggesting that these mechanisms are used in other developmental situations. In this context, we discuss the implementation of a common "budding toolkit" between the cecum and the limbs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.