ReviewMolecular phylogenetics and evolution2014
Evolution of glucose utilization: glucokinase and glucokinase regulator protein.
Review in Molecular phylogenetics and evolution, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 54 citations in OpenAlex.
- The Road so Far: Tracing the Molecular Evolution of Hexokinase Family in Metazoa.Genome biology and evolution · 2026Article
- Genomic architecture of purebred and crossbred Moghani lambs with Texel and Booroola sheep.Scientific reports · 2025Article
- Article
- Clinical report and genetic analysis of a Chinese family with retinitis pigmentosa 79 caused by a novel loss-of-function HK1 variant.Genes & genomics · 2024Article
- Pigmented paravenous chorioretinal atrophy: Updated scenario.European journal of ophthalmology · 2024Review
- Case Report: Hypoglycemia Due to a Novel Activating Glucokinase Variant in an Adult - a Molecular Approach.Frontiers in endocrinology · 2022Article
- Functional Inactivation ofInternational journal of molecular sciences · 2021Article
- Variation in the Evolution and Sequences of Proglucagon and the Receptors for Proglucagon-Derived Peptides in Mammals.Frontiers in endocrinology · 2021Article
- Moonlighting Proteins: The Case of the Hexokinases.Frontiers in molecular biosciences · 2021Review
- Selective Alanine Transporter Utilization Creates a Targetable Metabolic Niche in Pancreatic Cancer.Cancer discovery · 2020Article
- Review article: the emerging role of genetics in precision medicine for patients with non-alcoholic steatohepatitis.Alimentary pharmacology & therapeutics · 2020Review
- Article
- Hypoglycemic effects of esculeoside A are mediated via activation of AMPK and upregulation of IRS-1.BMC complementary and alternative medicine · 2019Article
- Replication of previous genome-wide association studies ofDiabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- The Destiny of Glucose from a MicroRNA Perspective.Frontiers in endocrinology · 2018Review
- Genetics of Gestational Diabetes Mellitus and Maternal Metabolism.Current diabetes reports · 2016Review
- Glucokinase mutation-a rare cause of recurrent hypoglycemia in adults: a case report and literature review.Journal of community hospital internal medicine perspectives · 2016Article
- Functional diversification and specialization of cytosolic 70-kDa heat shock proteins.Scientific reports · 2015Article
- Genetic Variants Associated with Lipid Profiles in Chinese Patients with Type 2 Diabetes.PloS one · 2015Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Glucose is an essential nutrient that must be distributed throughout the body to provide energy to sustain physiological functions. Glucose is delivered to distant tissues via be blood stream, and complex systems have evolved to maintain the levels of glucose within a narrow physiological range. Phosphorylation of glucose, by glucokinase, is an essential component of glucose homeostasis, both from the regulatory and metabolic point-of-view. Here we review the evolution of glucose utilization from the perspective of glucokinase. We discuss the origin of glucokinase, its evolution within the hexokinase gene family, and the evolution of its interacting regulatory partner, glucokinase regulatory protein (GCKR). Evolution of the structure and sequence of both glucokinase and GCKR have been necessary to optimize glucokinase in its role in glucose metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.