ArticleDevelopmental biology2013
tal1 Regulates the formation of intercellular junctions and the maintenance of identity in the endocardium.
Article in Developmental biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 45 citations in OpenAlex.
- Hedgehog and Bmp signaling pathways play opposing roles during establishment of the cardiac inflow tract in zebrafish.Development (Cambridge, England) · 2026Article
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- KnowYourCG: Facilitating base-level sparse methylome interpretation.Science advances · 2025Article
- Contraction-induced endocardialeLife · 2025Article
- Zebrafish smarcc1a mutants reveal requirements for BAF chromatin remodeling complexes in distinguishing the atrioventricular canal from the cardiac chambers.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- The regenerative response of cardiac interstitial cells.Journal of molecular cell biology · 2023Article
- Endocardial identity is established during early somitogenesis by Bmp signalling acting upstream of npas4l and etv2.Development (Cambridge, England) · 2022Article
- Using Live Imaging to Examine Early Cardiac Development in Zebrafish.Methods in molecular biology (Clifton, N.J.) · 2022Article
- The Zebrafish Cardiac Endothelial Cell-Roles in Development and Regeneration.Journal of cardiovascular development and disease · 2021Review
- Gene regulation could be attributed to TCF3 and other key transcription factors in the muscle of pubertal heifers.Veterinary medicine and science · 2020Article
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- Cardiac function modulates endocardial cell dynamics to shape the cardiac outflow tract.Development (Cambridge, England) · 2020Article
- Canonical Wnt5b Signaling Directs Outlying Nkx2.5+ Mesoderm into Pacemaker Cardiomyocytes.Developmental cell · 2019Article
- Nr2f-dependent allocation of ventricular cardiomyocyte and pharyngeal muscle progenitors.PLoS genetics · 2019Article
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- FGF signaling enforces cardiac chamber identity in the developing ventricle.Development (Cambridge, England) · 2017Article
- Myocardial plasticity: cardiac development, regeneration and disease.Current opinion in genetics & development · 2016Review
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- Strategies for analyzing cardiac phenotypes in the zebrafish embryo.Methods in cell biology · 2016Article
- Pbx4 is Required for the Temporal Onset of Zebrafish Myocardial Differentiation.Journal of developmental biologyArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
The endocardium forms the inner lining of the heart tube, where it enables blood flow and also interacts with the myocardium during the formation of valves and trabeculae. Although a number of studies have identified regulators in the morphogenesis of the myocardium, relatively little is known about the molecules that control endocardial morphogenesis. Prior work has implicated the bHLH transcription factor Tal1 in endocardial tube formation: in zebrafish embryos lacking Tal1, endocardial cells form a disorganized mass within the ventricle and do not populate the atrium. Through blastomere transplantation, we find that tal1 plays a cell-autonomous role in regulating endocardial extension, suggesting that Tal1 activity influences the behavior of individual endocardial cells. The defects in endocardial behavior in tal1-deficient embryos originate during the earliest steps of endocardial morphogenesis: tal1-deficient endocardial cells fail to generate a cohesive monolayer at the midline and instead pack tightly together into a multi-layered aggregate. Moreover, the tight junction protein ZO-1 is mislocalized in the tal1-deficient endocardium, indicating a defect in intercellular junction formation. In addition, we find that the tal1-deficient endocardium fails to maintain its identity; over time, a progressively increasing number of tal1-deficient endocardial cells initiate myocardial gene expression. However, the onset of defects in intercellular junction formation precedes the onset of ectopic myocardial gene expression in the tal1-deficient endocardium. We therefore propose a model in which Tal1 has distinct roles in regulating the formation of endocardial intercellular junctions and maintaining endocardial identity.
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