Evidence map›Paper›PMID 24075870›Full record

ReviewJournal of molecular biology2013

Innate immune response to arenaviral infection: a focus on the highly pathogenic New World hemorrhagic arenaviruses.

Takaaki Koma, Cheng Huang, Olga A Kolokoltsova, Allan R Brasier, Slobodan Paessler

Abstract readReview
In one paragraph

Review in Journal of molecular biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 27 citations in OpenAlex.

  1. Nociceptor neurons shape antiviral immunity.Journal of neuroinflammation · 2026
    Review
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  18. Type I interferon is a therapeutic target for virus-induced lethal vascular damage.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  19. Article
  20. Antiviral innate immunity: editorial overview.Journal of molecular biology · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Takaaki KomaDepartment of Pathology and Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, TX 77550, USA.
Cheng Huang
Olga A Kolokoltsova
Allan R Brasier
Slobodan Paessler
The University of Texas Medical Branch at Galveston · US

Funding

Recombinant life attenuated vaccine against Argentine hemorrhagic feverR01AI093445 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI DE LA TORRE, JUAN C., PAESSLER, SLOBODAN · 2011 to 2015
$4.6M
NIAID NIH HHS R01 AI093445NIAID NIH HHS R01AI093445
6 · The paper itself

Abstract

Arenaviruses are enveloped, negative-stranded RNA viruses that belong to the family Arenaviridae. This diverse family can be further classified into OW (Old World) and NW (New World) arenaviruses based on their antigenicity, phylogeny, and geographical distribution. Many of the NW arenaviruses are highly pathogenic viruses that cause systemic human infections characterized by hemorrhagic fever and/or neurological manifestations, constituting public health problems in their endemic regions. NW arenavirus infection induces a variety of host innate immune responses, which could contribute to the viral pathogenesis and/or influence the final outcome of virus infection in vitro and in vivo. On the other hand, NW arenaviruses have also developed several strategies to counteract the host innate immune response. We will review current knowledge regarding the interplay between the host innate immune response and NW arenavirus infection in vitro and in vivo, with emphasis on viral-encoded proteins and their effect on the type I interferon response.

Indexed as

AnimalsArenaviridae InfectionsArenaviruses, New WorldArenaviruses, Old WorldHost-Pathogen InteractionsHumansImmune EvasionImmunity, InnateInterferon Type IMiceModels, MolecularViral ProteinsInterferon Type IViral ProteinsAHFarenavirusArgentine hemorrhagic fevercytokinedouble-stranded RNAdsRNAglycoprotein precursorGPCIFN-stimulated geneinnate immunityinterferoninterferon antagonistISGNPnucleoproteinsingle-stranded RNAssRNAVHFviral hemorrhagic fever

Identifiers

PMID24075870
PMCPMC3864108
OpenAlexW1971105346

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.