No association of 9p21 with arterial elasticity and retinal microvascular findings.
Aaron R Folsom, James S Pankow, Xiaohui Li, Daniel A Duprez, David R Jacobs, Ronald Klein, Barbara Klein, Weihong Tang, Tien Yin Wong, Mary Frances Cotch and 5 more
Article in Atherosclerosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literature
Who cites it
1 citing paper in PubMed, 1 citations in OpenAlex.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors at 7 institutions in 2 countries.
Aaron R FolsomDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA. Electronic address: folso001@umn.edu.
James S Pankow
Xiaohui Li
Daniel A Duprez
David R Jacobs
Ronald Klein
Barbara Klein
Weihong Tang
Tien Yin Wong
Mary Frances Cotch
Kent D Taylor
Stephen S Rich
Jennifer L Hall
Wendy S Post
Jerome I Rotter
University of Minnesota · USHarbor–UCLA Medical Center · USUniversity of Wisconsin–Madison · USJohns Hopkins University · USNational Eye Institute · USSingapore National Eye Center · SGUniversity of Virginia · US
Funding
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Multi-ethnic Study Of Atherosclerosis - Vision ComponentZIAEY000403 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2009 to 2020
$1.8M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
SUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTER-N01HC95159-268095159N01HC095159 · HC · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 1999 to 2006
$304k
Multi-ethnic Study Of Atherosclerosis - Vision ComponentZ01EY000403 · NEI · NATIONAL EYE INSTITUTE · PI COTCH, MARY FRANCES · 2002 to 2008
$150k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READINGN01HC095169 · HC · LA BIOMED RES INST/ HARBOR UCLA MED CTR · PI DETRANO, ROBERT · 1999 to 2001
objectiveHow 9p21 variation affects risk of cardiovascular disease is unclear, so we assessed whether 9p21 variants are associated with arterial elasticity or retinal microvascular findings.
methodsIn the prospective Multi-Ethnic Study of Atherosclerosis (MESA) we assessed 378 SNPs in the 9p21 locus. Within four ethnic groups, we used an additive genetic model to relate the 9p21 SNPs to five vascular phenotypes: small and large elasticity derived from radial diastolic pulse contour analysis; Young's elastic modulus from carotid artery ultrasound measurements; and the diameter of the central retinal arteries and veins.
resultsIn neither ethnic-specific nor pooled data was there any statistically significant association between any of the 9p21 SNPs and any of the five vascular phenotypes.
conclusionOur study does not support an association of 9p21 variation with arterial elasticity or retinal microvascular abnormalities.
Indexed as
Chromosomes, Human, Pair 9MicrocirculationPolymorphism, Single NucleotideVascular StiffnessAgedAged, 80 and overAllelesArteriesAtherosclerosisCarotid ArteriesElasticityEndothelium, VascularEthnicityFemaleHumansLinear Models9p21 SNPArterial elasticityProspective studyRetinal microvascular abnormalities
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
No association of 9p21 with arterial elasticity and retinal microvascular findings. · full record | OpenQuestion