Evidence map›Paper›PMID 24075755›Full record

ArticleAtherosclerosis2013

The prospective association of Chlamydia pneumoniae and four other pathogens with development of coronary artery calcium: the multi-ethnic study of atherosclerosis (MESA).

Babray Laek, Moyses Szklo, Robyn L McClelland, Jingzhong Ding, Michael Y Tsai, David A Bluemke, Russell Tracy, Kunihiro Matsushita

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Atherosclerosis, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Role ofBiomedicines · 2024
    Review
  2. Life (Basel, Switzerland) · 2023
    Article
  3. Fecal Microbiota Composition as a Metagenomic Biomarker of Dietary Intake.International journal of molecular sciences · 2023
    Review
  4. Article
  5. Therapeutics and clinical risk management · 2017
    Article
  6. Article
  7. Role of Chlamydia pneumoniae and Helicobacteria pylori in the development of tympanosclerosis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016
    Article
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 6 institutions in 1 country.

Babray LaekDepartment of Epidemiology, Johns Hopkins University, 615 North Wolfe Street, Baltimore, MD 21205, USA; Netherlands Institute for Health Sciences, Erasmus University, Dr. Molewaterplein 60, 3015 GJ Rotterdam, The Netherlands. Electronic address: babraylaek@gmail.com.
Moyses Szklo
Robyn L McClelland
Jingzhong Ding
Michael Y Tsai
David A Bluemke
Russell Tracy
Kunihiro Matsushita
Johns Hopkins University · USNational Institutes of Health · USUniversity of Minnesota · USUniversity of Vermont · USUniversity of Washington · USWake Forest University · US

Funding

RESPIRATORY RESEARCH TRAINING PROGRAMT32HL007287 · NHLBI · UNIVERSITY OF WASHINGTON · PI Kristina Anne Crothers, David J. Horne · 1985 to 2026
$16.7M
Molecular Biomedical Imaging Laboratory (NIBIB)ZIAEB000072 · NIBIB · NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING · PI BLUEMKE, DAVID · 2010 to 2017
$5.0M
Regional Dysfunction by MRI in Incident Heart FailureR01HL066075 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI LIMA, JOAO A C · 2001 to 2009
$4.0M
Endothelial Dysfunction and the RV in the Multi-Ethnic Study of AtherosclerosisR01HL086719 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2007 to 2010
$2.0M
Mentored Patient-Oriented Research in Pulmonary Arterial HypertensionK24HL103844 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KAWUT, STEVEN M · 2011 to 2020
$1.6M
MYOCARDIAL PERFUSION, RISK FACTORS, AND CORONARY CALCIUMR01HL065580 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI JEROSCH-HEROLD, MICHAEL · 2000 to 2003
$1.3M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
NHLBI NIH HHS K23-HL103844NHLBI NIH HHS K24 HL103844NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N01-HC- 95159NHLBI NIH HHS N01-HC-95169NHLBI NIH HHS R01 HL065580NHLBI NIH HHS R01 HL066075NHLBI NIH HHS R01 HL086719NHLBI NIH HHS R01-HL086719NHLBI NIH HHS R01-HL-65580-01NHLBI NIH HHS R01-HL66075-01NHLBI NIH HHS T32 HL007287NHLBI NIH HHS T32-HL007287-33
6 · The paper itself

Abstract

objectivePrevious basic and cross-sectional studies obtained conflicting results regarding the association of pathogens with coronary artery calcium (CAC). The aim of this study is to prospectively evaluate this association in a population-based cohort.

methodsWe examined 5744 individuals aged 45-84 years at baseline (2000-02) who underwent repeated CAC assessment on average 2.4 years later (a half at visit 2 [2002-04] and the other half at visit 3 [2004-05]). CAC incidence was defined as newly detectable CAC at follow-up (475 cases of 2942 participants). CAC progression was defined as annualized change in CAC Agatston score ≥10 units/year if baseline CAC score >0 to <100 or ≥10%/year if baseline score ≥ 100 (1537 cases of 2802 participants). Seropositivity was assessed in the entire cohort for Chlamydia pneumoniae and in a random sample (n = 873) for Helicobacter pylori, cytomegalovirus, herpes simplex virus, and hepatitis A virus.

resultsSeropositivity to C. pneumoniae was not significantly associated with CAC incidence (odds ratio [OR] 1.11 [95% CI, 0.88-1.39], P = 0.371) or progression (1.14 [0.96-1.36], P = 0.135) even in unadjusted models. When CAC incidence and progression were combined, we observed significant association with C. pneumoniae seropositivity before adjustment (OR 1.17 [1.03-1.33], P = 0.016) but not in a model adjusting for traditional risk factors (1.04 [0.90-1.19], P = 0.611). The results were consistent across subgroups according to age, sex, and race/ethnicity. None of five pathogens or their accrual was associated with CAC incidence and progression in the subsample.

conclusionOur prospective study does not support the pathophysiological involvement of these pathogens in CAC development.

Indexed as

Chlamydophila pneumoniaeAgedAged, 80 and overAtherosclerosisCalcinosisCalciumCoronary VesselsCytomegalovirusCytomegalovirus InfectionsDisease ProgressionFemaleHelicobacter InfectionsHelicobacter pyloriHepatitis AHepatitis A virusHerpes SimplexCalciumAtherosclerosisCoronary calciumInfectionPathogens

Identifiers

PMID24075755
PMCPMC3815605
OpenAlexW1997785177

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.