Evidence map›Paper›PMID 24075505›Full record

Trial reportMetabolism: clinical and experimental2013

Consuming a hypocaloric high fat low carbohydrate diet for 12 weeks lowers C-reactive protein, and raises serum adiponectin and high density lipoprotein-cholesterol in obese subjects.

Megan R Ruth, Ava M Port, Mitali Shah, Ashley C Bourland, Nawfal W Istfan, Kerrie P Nelson, Noyan Gokce, Caroline M Apovian

Erratum issued Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Metabolism: clinical and experimental, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03372109 (A Randomized Controlled Trial to Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain in Overweight But Generally Healthy Adults Over the Winter Holiday Period), which is not on this map. Cited by 63 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed, 14 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03372109 nacompletednot on this mapstarted 2017, after this paper: background citation

A Randomized Controlled Trial to Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain in Overweight But Generally Healthy Adults Over the Winter Holiday Period

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2017 to 2018Enrolled23ConditionsBody Weight ChangesArmsMeal replacement shake, Multivitamin and mineral capsules, Fish oil with sesame lignans and olive extract softgel, Prebiotic Chewable tablet, Clove Extract and Maqui Berry extract capsule
3 · Its place in the literature

Who cites it

63 citing papers in PubMed, 14 syntheses or guidelines pooled it, 127 citations in OpenAlex.

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  20. Reliability and diagnostic performance of a new blood ketone and glucose meter in humans.Journal of the International Society of Sports Nutrition · 2021
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3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Megan R RuthDepartment of Medicine, Section of Endocrinology, Diabetes and Nutrition, Boston University, 88 E. Newton St., Suite D4400, Boston, MA 02118.
Ava M Port
Mitali Shah
Ashley C Bourland
Nawfal W Istfan
Kerrie P Nelson
Noyan Gokce
Caroline M Apovian
Boston University · US

Funding

Redox regulation in Endothelial Progenitor CellsP01HL081587 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALSH, KENNETH · 2005 to 2015
$21.5M
YOGA INDUCED CHANGES IN BRAIN GABA LEVELSM01RR000533 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI HOLICK, MICHAEL F. · 1985 to 2008
$19.4M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR025771 · NCRR · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2008 to 2011
$17.6M
Boston University Clinical and Translational Science Award (CTSA) Program UL1UL1TR000157 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI CENTER, DAVID M. · 2012 to 2013
$7.9M
Adipose inflammation, mitochondrial function & endothelial phenotypes in obesityR01HL114675 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GOKCE, NOYAN · 2012 to 2016
$2.3M
NCATS NIH HHS UL1 TR000157NCRR NIH HHS M01 RR000533NCRR NIH HHS U54 RR025771NCRR NIH HHS UL1 RR025771NHLBI NIH HHS P01 HL081587NHLBI NIH HHS R01 HL114675
6 · The paper itself

Abstract

objectiveHigh fat, low carbohydrate (HFLC) diets have become popular tools for weight management. We sought to determine the effects of a HFLC diet compared to a low fat high carbohydrate (LFHC) diet on the change in weight loss, cardiovascular risk factors and inflammation in subjects with obesity.

methodsObese subjects (29.0-44.6 kg/m2) recruited from Boston Medical Center were randomized to a hypocaloric LFHC (n=26) or HFLC (n=29) diet for 12 weeks.

resultsThe age range of subjects was 21-62 years. As a percentage of daily calories, the HFLC group consumed 33.5% protein, 56.0% fat and 9.6% carbohydrate and the LFHC group consumed 22.0% protein, 25.0% fat and 55.7% carbohydrate. The change in percent body weight, lean and fat mass, blood pressure, flow mediated dilation, hip:waist ratio, hemoglobin A1C, fasting insulin and glucose, and glucose and insulin response to a 2h oral glucose tolerance test did not differ (P>0.05) between diets after 12 weeks. The HFLC group had greater mean decreases in serum triglyceride (P=0.07), and hs-CRP (P=0.03), and greater mean increases in HDL cholesterol (P=0.004), and total adiponectin (P=0.045) relative to the LFHC. Secreted adipose tissue adiponectin or TNF-α did not differ after weight loss for either diet.

conclusionsRelative to the LFHC group, the HFLC group had greater improvements in blood lipids and systemic inflammation with similar changes in body weight and composition. This small-scale study suggests that HFLC diets may be more beneficial to cardiovascular health and inflammation in free-living obese adults compared to LFHC diets.

Indexed as

Caloric RestrictionDiet, Carbohydrate-RestrictedDiet, High-FatAdiponectinAdipose TissueAdultAnthropometryBlood GlucoseBody CompositionBody Mass IndexCholesterol, HDLC-Reactive ProteinFemaleGlucose Tolerance TestHemodynamicsHumansAdiponectinBlood GlucoseCholesterol, HDLC-Reactive ProteinLipoproteins, HDLarea under the curveAUCBMIbody mass indexCardiovasculardual energy x-ray absorptiometryDXAELISAenzyme-linked immunosorbent assayflow mediated dilationFMDHbA1CHDLhemoglobin A1CHFLChigh density lipoproteinhigh fat low carbohydratehigh molecular weighthigh sensitivity-C-reactive proteinHMWHOMA-IRhomeostatic model assessment-insulin resistancehs-CRPInflammationLDLLFHClow density lipoproteinlow fat high carbohydrateMacronutrientsOGTToral glucose tolerance testTNF-αtumor necrosis factor-alphaWeight loss

Identifiers

PMID24075505
PMCPMC3845365
OpenAlexW2042285392

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.