ArticleBiomaterials2013
Engineering functional anisotropy in fibrocartilage neotissues.
Article in Biomaterials, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 66 citations in OpenAlex.
- Differentiated Stem Cell-Seeded Gelatin/PLA/P(3HB-co-4HB) Meniscal Scaffold with Biocompatibility and Mechanical Strength.Polymers · 2026Article
- 3D imaging and anisotropy mapping of the lamb disc for biomechanical and regenerative insights.Frontiers in physiology · 2026Article
- Minipig costal and knee cartilage structure-function relationships and their use as cell sources for tissue-engineered analogous cellular products for cartilage repair.Acta biomaterialia · 2026Article
- Bioactive scaffolds integrated with micro-precise spatiotemporal delivery andEngineered regeneration · 2025Article
- Challenges and recent advances in engineering the osteochondral interface.Current opinion in biomedical engineering · 2024Article
- Auricular Chondrocytes as a Cell Source for Scaffold-Free Elastic Cartilage Tissue Engineering.Tissue engineering. Part C, Methods · 2024Article
- A cell bank paradigm for preclinical evaluation of an analogous cellular product for an allogeneic cell therapy.Biofabrication · 2024Article
- Navigating regulatory pathways for translation of biologic cartilage repair products.Science translational medicine · 2022Review
- Inductive Remodeling of Extracellular Matrix Scaffolds in the Temporomandibular Joint of Pigs.Tissue engineering. Part A · 2022Article
- Advances in Regenerative Sports Medicine Research.Frontiers in bioengineering and biotechnology · 2022Review
- Advances in Tissue Engineering of the Temporomandibular Joint Disc: An Overview of Current Status and Future Directions.International journal of dentistry · 2022Review
- Research progress on tissue engineering in repairing tempomandibular joint.Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021Article
- Meniscal Regenerative Scaffolds Based on Biopolymers and Polymers: Recent Status and Applications.Frontiers in cell and developmental biology · 2021Review
- 3D-bioprinting ready-to-implant anisotropic menisci recapitulate healthy meniscus phenotype and prevent secondary joint degeneration.Theranostics · 2021Article
- Hybrid Bioprinting of Zonally Stratified Human Articular Cartilage Using Scaffold-Free Tissue Strands as Building Blocks.Advanced healthcare materials · 2020Article
- Surgical and tissue engineering strategies for articular cartilage and meniscus repair.Nature reviews. Rheumatology · 2019Review
- Structure-function relationships of fetal ovine articular cartilage.Acta biomaterialia · 2019Article
- Remaining Hurdles for Tissue-Engineering the Temporomandibular Joint Disc.Trends in molecular medicine · 2019Review
- Considerations for translation of tissue engineered fibrocartilage from bench to bedside.Journal of biomechanical engineering · 2018Article
- Tissue engineering toward temporomandibular joint disc regeneration.Science translational medicine · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The knee meniscus, intervertebral disc, and temporomandibular joint (TMJ) disc all possess complex geometric shapes and anisotropic matrix organization. While these characteristics are imperative for proper tissue function, they are seldom recapitulated following injury or disease. Thus, this study's objective was to engineer fibrocartilages that capture both gross and molecular structural features of native tissues. Self-assembled TMJ discs were selected as the model system, as the disc exhibits a unique biconcave shape and functional anisotropy. To drive anisotropy, 50:50 co-cultures of meniscus cells and articular chondrocytes were grown in biconcave, TMJ-shaped molds and treated with two exogenous stimuli: biomechanical (BM) stimulation via passive axial compression and bioactive agent (BA) stimulation via chondroitinase-ABC and transforming growth factor-β1. BM + BA synergistically increased Col/WW, Young's modulus, and ultimate tensile strength 5.8-fold, 14.7-fold, and 13.8-fold that of controls, respectively; it also promoted collagen fibril alignment akin to native tissue. Finite element analysis found BM stimulation to create direction-dependent strains within the neotissue, suggesting shape plays an essential role toward driving in vitro anisotropic neotissue development. Methods used in this study offer insight on the ability to achieve physiologic anisotropy in biomaterials through the strategic application of spatial, biomechanical, and biochemical cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.