ArticleAsian Pacific journal of tropical biomedicine2013
African eggplant (Solanum anguivi Lam.) fruit with bioactive polyphenolic compounds exerts in vitro antioxidant properties and inhibits Ca(2+)-induced mitochondrial swelling.
Article in Asian Pacific journal of tropical biomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
- Bioactive fractions ofMetabolism open · 2026Article
- Effect of Dalbergiella welwitschi alkaloid-rich leaf extracts on testicular damage in streptozotocin-induced diabetic rats.Journal of molecular histology · 2025Article
- Biochemical and biological studies of irradiated and non-irradiated extracts of Solanum aculeastrum Dunal fruit.Scientific reports · 2024Article
- Anti-diabetic, anti-pancreatic lipase, and anti-protein glycation potential ofIn silico pharmacology · 2024Article
- Influence of ripeness stage on the bioactive compounds' contents and antioxidant activities ofHeliyon · 2023Article
- Article
- Genetic Diversity and Utilization of Cultivated Eggplant Germplasm in Varietal Improvement.Plants (Basel, Switzerland) · 2021Review
- Genetics and breeding for climate change in Orphan crops.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Review
- Review
- Solanum Fruits: Phytochemicals, Bioaccessibility and Bioavailability, and Their Relationship With Their Health-Promoting Effects.Frontiers in nutrition · 2021Review
- Antitrypanosomal Effect of Hydromethanolic Extract ofJournal of parasitology research · 2021Article
- The Genus Solanum: An Ethnopharmacological, Phytochemical and Biological Properties Review.Natural products and bioprospecting · 2019Review
- Scientific validation of medicinal plants used by Yakkha community of Chanuwa VDC, Dhankuta, Nepal.SpringerPlus · 2016Article
- Ethnobotanical survey and toxicity evaluation of medicinal plants used for fungal remedy in the Southern Highlands of Tanzania.Journal of intercultural ethnopharmacologyArticle
- Effects of Tapinanthus globiferus and Zanthoxylum zanthoxyloides extracts on human leukocytes in vitro.Journal of intercultural ethnopharmacologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the antioxidant and radical scavenging activities of Solanum anguivi fruit (SAG) and its possible effect on mitochondrial permeability transition pore as well as mitochondrial membrane potential (ΔΨm) isolated from rat liver.
methodsAntioxidant activity of SAG was assayed by using 2,2-diphenyl-1-picrylhydrazyl (DPPH), reducing power, iron chelation and ability to inhibit lipid peroxidation in both liver and brain homogenate of rats. Also, the effect of SAG on mitochondrial membrane potential and mitochondrial swelling were determined. Identification and quantification of bioactive polyphenolics was done by HPLC-DAD.
resultsSAG exhibited potent and concentration dependent free radical-scavenging activity (IC50/DPPH=275.03±7.8 μg/mL). Reductive and iron chelation abilities also increase with increase in SAG concentration. SAG also inhibited peroxidation of cerebral and hepatic lipids subjected to iron oxidative assault. SAG protected against Ca(2+) (110 μmol/L)-induced mitochondrial swelling and maintained the ΔΨm. HPLC analysis revealed the presence of gallic acid [(17.54±0.04) mg/g], chlorogenic acid (21.90±0.02 mg/g), caffeic acid (16.64±0.01 mg/g), rutin [(14.71±0.03) mg/g] and quercetin [(7.39±0.05) mg/g].
conclusionsThese effects could be attributed to the bioactive polyphenolic compounds present in the extract. Our results suggest that SAG extract is a potential source of natural antioxidants that may be used not only in pharmaceutical and food industry but also in the treatment of diseases associated with oxidative stress.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.