ArticleJournal of critical care2014
A pilot investigation of the association of genetic polymorphisms regulating corticotrophin-releasing hormone with posttraumatic stress and depressive symptoms in medical-surgical intensive care unit survivors.
Article in Journal of critical care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04305353 (Implementing an Intensive Care Unit), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Implementing an Intensive Care Unit (ICU) Diary Program at a Large Academic Medical Center: Results From a Randomized Control Trial Evaluating Psychological Morbidity Associated With Critical Illness
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Meta-Analysis of Associations Between Hypothalamic-Pituitary-Adrenal Axis Genes and Risk of Posttraumatic Stress Disorder.Journal of traumatic stress · 2020Pooled it
- Implementing an intensive care unit (ICU) diary program at a large academic medical center: Results from a randomized control trial evaluating psychological morbidity associated with critical illness.General hospital psychiatryTrial
- Glucocorticoids and the Brain after Critical Illness.Endocrinology · 2021Review
- Aneurysmal subarachnoid haemorrhage: effect of CRHR1 genotype on fatigue and depression.BMC neurology · 2020Article
- Aneurysmal subarachnoid haemorrhage: Effect of CRHR1 genotype on mental health-related quality of life.Scientific reports · 2020Article
- Glucocorticoids and resilience.Hormones and behavior · 2019Review
- Timing of prenatal exposure to trauma and altered placental expressions of hypothalamic-pituitary-adrenal axis genes and genes driving neurodevelopment.Journal of neuroendocrinology · 2018Article
- Intensive Care Unit Delirium and Intensive Care Unit-Related Posttraumatic Stress Disorder.The Surgical clinics of North America · 2017Review
- Corticotropin-releasing hormone-binding protein and stress: from invertebrates to humans.Stress (Amsterdam, Netherlands) · 2017Review
- Incidence and Risk Factors for Intensive Care Unit-related Post-traumatic Stress Disorder in Veterans and Civilians.American journal of respiratory and critical care medicine · 2016Observational
- Associations between Single-Nucleotide Polymorphisms in Corticotropin-Releasing Hormone-Related Genes and Irritable Bowel Syndrome.PloS one · 2016Article
- Steroids for acute respiratory distress syndrome?Clinics in chest medicine · 2014Review
- Posttraumatic stress disorder among survivors of critical illness: creation of a conceptual model addressing identification, prevention, and management.Intensive care medicine · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo determine if single nucleotide polymorphisms of the corticotrophin-releasing hormone binding protein (CRHBP, rs10055255) and CRH receptor type 1 (CRHR1, rs1876831) were associated with posttraumatic stress disorder (PTSD) and depressive symptoms following medical-surgical intensive care unit (ICU) hospitalization. MATERIALS AND
methodsWe extracted DNA for genotyping from saliva samples of 93 ICU patients enrolled in a prospective cohort investigation. Follow-up interviews conducted 3 and 12-months post-ICU included assessment of PTSD symptoms with the PTSD Checklist-Civilian Version and depressive symptoms with the Patient Health Questionnaire-9.
resultsHomozygosity for the CRHBP rs10055255 T allele was associated with significantly fewer post-ICU PTSD (β = -10.8, 95% confidence interval [95% CI], -17.7 to -3.9; P = .002) and depressive symptoms (β = -3.7, 95% CI, -6.7 to -0.7; P = .02). Carrying a CRHR1 rs1876831 C allele was associated with significantly more post-ICU depressive symptoms compared to T/T homozygotes (C/T heterozygtes: β = 6.9, 95% CI, 1.2-12.6; P = .02; C/C homozygotes: β = 5.8; 95% CI: 0.2-11.3; P = .04). These associations remained significant after adjustment for age, race, illness severity, and in-ICU steroid exposure.
conclusionsDespite a small sample size, our findings suggest a potential role for genetic variants of CRHBP and CRHR1 in the development of post-ICU psychiatric morbidity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.