ArticleAmerican journal of human genetics2013
The IL-33-ST2L pathway is associated with coronary artery disease in a Chinese Han population.
Article in American journal of human genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- IL-33/ST2 immunobiology in coronary artery disease: A systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2022Pooled it
- A candidate gene approach identifies an IL33 genetic variant as a novel genetic risk factor for GCA.PloS one · 2014Pooled it
- Potential Inflammatory Mediators in Pericardial Fluids of Patients With Coronary Artery Diseases and Their Association With Plasma Biomarkers.Journal of cellular and molecular medicine · 2025Article
- The differential role of IL-33 and IL-38 in prostate cancer, contradictory roles.Frontiers in immunology · 2025Review
- The Influence of Genetic Polymorphisms ofInternational journal of dentistry · 2025Article
- Genetic variant rs2243115 of the IL-12/IL-35 pathway contributes to the risk of coronary artery disease.International journal of medical sciences · 2025Article
- Polymorphism of IL-12/IL-23 axis is associated with coronary heart disease.Journal of cellular and molecular medicine · 2024Article
- Frequency distribution of cytokine and associated transcription factor single nucleotide polymorphisms in Zimbabweans: Impact on schistosome infection and cytokine levels.PLoS neglected tropical diseases · 2022Article
- Synergistic Effects of Weighted Genetic Risk Scores and Resistin and sST2 Levels on the Prognostication of Long-Term Outcomes in Patients with Coronary Artery Disease.International journal of molecular sciences · 2022Article
- Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding.The journal of physical chemistry. B · 2022Article
- Functional rare variant in aAging · 2021Article
- Role of the IL33 and IL1RL1 pathway in the pathogenesis of Immunoglobulin A vasculitis.Scientific reports · 2021Article
- Article
- Genetic Association of Interleukin 33/ST2 Polymorphisms With Behcet's Uveitis.Frontiers in immunology · 2021Article
- Insights into the genetic basis ofCardiovascular diagnosis and therapy · 2020Article
- Statistical and Functional Studies Identify Epistasis of Cardiovascular Risk Genomic Variants From Genome-Wide Association Studies.Journal of the American Heart Association · 2020Article
- Global landscape of mouse and human cytokine transcriptional regulation.Nucleic acids research · 2018Article
- Association of COL4A1 (rs605143, rs565470) and CD14 (rs2569190) genes polymorphism with coronary artery disease.Molecular and cellular biochemistry · 2018Article
- Association between functional polymorphisms in IL-33/ST2 pathway and risk of osteosarcoma.Journal of cellular and molecular medicine · 2018Article
- Significant Association between OPG/TNFRSF11B Variant and Common Complex Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2018Article
Corrections and comments
- Erratum issued
Authors and funding
27 authors at 10 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effects of interleukin-33 (IL-33) on the immune system have been clearly demonstrated; however, in cardiovascular diseases, especially in coronary artery disease (CAD), these effects have not yet been clarified. In this study, we investigate the genetic role of the IL-33-ST2L pathway in CAD. We performed three-stage case-control association analyses on a total of 4,521 individuals with CAD and 4,809 controls via tag SNPs in the genes encoding IL-33 and ST2L-IL-1RL1. One tag SNP in each gene was significantly associated with CAD (rs7025417(T) in IL33, padj = 1.19 × 10(-28), OR = 1.39, 95% CI: 1.31-1.47; rs11685424(G) in IL1RL1, padj = 6.93 × 10(-30), OR = 1.40, 95% CI: 1.32-1.48). Combining significant variants in two genes, the risk for CAD increased nearly 5-fold (padj = 8.90 × 10(-21), OR = 4.98, 95% CI: 3.56-6.97). Traditional risk factors for CAD were adjusted for the association studies by SPSS with logistic regression analysis. With the two variants above, both located within the gene promoter regions, reporter gene analysis indicated that the rs7025417 C>T and rs11685424 A>G changes resulted in altered regulation of IL33 and IL1RL1 gene expression, respectively (p < 0.005). Further studies revealed that the rs7025417 genotype was significantly associated with plasma IL-33 levels in the detectable subjects (n = 227, R(2) = 0.276, p = 1.77 × 10(-17)): the level of IL-33 protein increased with the number of rs7025417 risk (T) alleles. Based on genetic evidence in humans, the IL-33-ST2L pathway appears to have a causal role in the development of CAD, highlighting this pathway as a valuable target for the prevention and treatment of CAD.
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