ArticlePsychiatry research2013
Reduced white matter integrity in the cingulum and anterior corona radiata in posttraumatic stress disorder in male combat veterans: a diffusion tensor imaging study.
Article in Psychiatry research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 6 of them syntheses that pooled it.
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Who cites it
79 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Biological and neurocognitive correlates of comorbid post-traumatic stress disorder and alcohol use disorder: a systematic review.European journal of psychotraumatology · 2026Pooled it
- Early life adversity and white matter microstructural organization-a systematic review.Brain imaging and behavior · 2025Pooled it
- Altered white matter microstructural organization in posttraumatic stress disorder across 3047 adults: results from the PGC-ENIGMA PTSD consortium.Molecular psychiatry · 2021Pooled it
- Abnormalities of Brain White Matter in Type 2 Diabetes Mellitus: A Meta-Analysis of Diffusion Tensor Imaging.Frontiers in aging neuroscience · 2021Pooled it
- A Systematic Literature Review of Neuroimaging of Psychopathic Traits.Frontiers in psychiatry · 2019Pooled it
- Adolescent brain development and depression: A case for the importance of connectivity of the anterior cingulate cortex.Neuroscience and biobehavioral reviews · 2016Pooled it
- Effects of antidepressant medications on brain tissue microstructure in persistent depressive disorder across two randomized controlled trials.NeuroImage. Clinical · 2026Trial
- Trial
- The Influence of Acute SSRI Administration on White Matter Microstructure in Patients Suffering From Major Depressive Disorder and Healthy Controls.The international journal of neuropsychopharmacology · 2021Trial
- Neural changes following equine-assisted therapy for posttraumatic stress disorder: A longitudinal multimodal imaging study.Human brain mapping · 2021Trial
- Trial
- Associations between residential segregation, ambient air pollution, and hippocampal features in recent trauma survivors.Translational psychiatry · 2026Article
- Microstructural Integrity of Hippocampal-Posterior Cortical White Matter Is Associated With Phenomenological Properties of Trauma-Related Intrusive Memories.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Neuroplasticity in Post-Traumatic Stress Disorder.Revista de neurologia · 2025Review
- Age-dependent brain subcortical white and gray matter disruptions in patients with posttraumatic stress disorder.Anatomy & cell biology · 2025Article
- Connectometry reveals differing associations of cortisol and PACAP with dorsal cingulum microstructure in posttraumatic stress.medRxiv : the preprint server for health sciences · 2025Article
- Examination of the impact of curiosity and fatigue on brain condition.Scientific reports · 2025Article
- Kawaii-Ness Mediates Between Demographic Variables, Happiness, and Brain Conditions.Brain sciences · 2025Article
- Affective Visual Circuit Dysfunction in Trauma and Stress-Related Disorders.Biological psychiatry · 2025Review
- Deep learning-based image reconstruction benefits diffusion tensor imaging for assessing severity of depression.Frontiers in neuroscience · 2025Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors.
Funding
Abstract
Posttraumatic stress (PTSD) and alcohol use (AUD) disorders are associated with abnormal anterior cingulate cortex/ventromedial prefrontal cortex, thalamus, and amygdala function, yet microstructural white matter (WM) differences in executive-limbic tracts are likely also involved. Investigating WM in limbic-thalamo-cortical tracts, this study hypothesized (1) fractional anisotropy (FA) in dorsal cingulum, parahippocampal cingulum, and anterior corona radiata (ACR) would be lower in individuals with comorbid PTSD/AUD compared to in individuals with AUD-only and (2) that FA would be related to both AUD and PTSD severity. 22 combat veterans with comorbid PTSD/AUD or AUD-only completed DTI scans. ANCOVAs indicated lower FA in right (F(df=1,19)=9.091, P=0.0071) and left (F(df=1,19)=10.375, P=0.0045) dorsal cingulum and right ACR (F(df=1,19)=18.914, P=0.0003) for individuals with comorbid PTSD/AUD vs. individuals with AUD-only, even controlling for alcohol use. Multiple linear regressions revealed that FA in the right ACR was inversely related to PTSD severity (r=-0.683, P=0.004). FA was not significantly related to alcohol severity. Reduced WM integrity in limbic-thalamo-cortical tracts is implicated in PTSD, even in the presence of comorbid AUD. These findings suggest that diminished WM integrity in tracts important for top-down control may be an important anomaly in PTSD and/or comorbid PTSD/AUD.
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