ArticleVirology2013
An unbiased in vivo screen reveals multiple transcription factors that control HPV E6-regulated hTERT in keratinocytes.
Article in Virology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Rethinking residual p53 function in HPV-positive cervical cancer cells.Journal of virology · 2026Article
- PUF60-Regulated Isoform Switching of MAZ Modulates Gastric Cancer Cell Migration.Cancer medicine · 2025Article
- A CpG island promoter drives the CXXC5 gene expression.Scientific reports · 2021Article
- Mechanisms of TERT Reactivation and Its Interaction with BRAFV600E.Endocrinology and metabolism (Seoul, Korea) · 2020Review
- Interplay between TERT promoter mutations and methylation culminates in chromatin accessibility and TERT expression.PloS one · 2020Article
- Discovery of proteins associated with a predefined genomic locus via dCas9-APEX-mediated proximity labeling.Nature methods · 2018Article
- Telomere Maintenance Mechanisms in Cancer.Genes · 2018Review
- TIP60 represses telomerase expression by inhibiting Sp1 binding to the TERT promoter.PLoS pathogens · 2017Article
- Telomerase Induction in HPV Infection and Oncogenesis.Viruses · 2017Review
- Article
- Review
- Telomerase Expression by Aberrant Methylation of the TERT Promoter in Melanoma Arising in Giant Congenital Nevi.The Journal of investigative dermatology · 2016Article
- Human telomerase reverse transcriptase regulates vascular endothelial growth factor expression via human papillomavirus oncogene E7 in HPV-18-positive cervical cancer cells.Medical oncology (Northwood, London, England) · 2015Article
- Recent advances in the study of HPV-associated carcinogenesis.Virologica Sinica · 2015Review
- Longitudinal assessment of DNA methylation changes during HPVE6E7-induced immortalization of primary keratinocytes.Epigenetics · 2015Article
- The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors.Endocrine-related cancer · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Activation of telomerase by human papillomavirus 16 (HPV16) E6 is a critical step for cell immortalization and transformation in human foreskin keratinocytes (HFKs). Multiple transcription factors have been identified as being involved in E6-induced hTERT expression. Here, we adapted an unbiased in vivo screen using a LacO-LacI system in human cells to discover hTERT promoter-interacting regulators. This approach allowed us to identify a novel hTERT repressor, Maz, which bound the hTERT promoter. E6 expression reduced Maz binding and correspondingly increased Sp1 binding at the hTERT promoter. Knockdown of Maz further increased histone acetylation, as well as hTERT expression in the presence of E6. Overall, these data indicate the utility of a novel screen for promoter-interacting and transcription-regulating proteins. These data also highlight multiple factors that normally regulate hTERT repression in HFKs, and therefore are targeted by E6 for hTERT expression.
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Registered trials
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