ArticleJournal of the American Academy of Child and Adolescent Psychiatry2013
Altered cerebral perfusion in executive, affective, and motor networks during adolescent depression.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 82 citations in OpenAlex.
- Comorbid Anxiety and Depressive Symptoms in Children and Adolescents: A Systematic Review and Analysis.Journal of psychiatric practice · 2016Pooled it
- Trial
- Gamma-Hydroxybutyrate Increases Resting-State Limbic Perfusion and Body and Emotion Awareness in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Cerebral Blood Flow and Mood in Adolescents With Bipolar Disorder.JAACAP open · 2025Article
- Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First-Episode, Treatment-Naïve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study.Brain and behavior · 2025Article
- Abnormal voxel-wise whole-brain functional connectivity in first-episode, drug-naïve adolescents with major depression disorder.European child & adolescent psychiatry · 2023Article
- Aberrant temporal-spatial complexity of intrinsic fluctuations in major depression.European archives of psychiatry and clinical neuroscience · 2023Article
- Cerebral blood flow in adolescents with drug-naive, first-episode major depressive disorder: An arterial spin labeling study based on voxel-level whole-brain analysis.Frontiers in neuroscience · 2022Article
- Left amygdala volume and brain tissue pulsatility are associated with neuroticism: an MRI and ultrasound study.Brain imaging and behavior · 2021Article
- Cerebral Blood Flow Alterations in High Myopia: An Arterial Spin Labeling Study.Neural plasticity · 2020Article
- Study Protocol for Teen Inflammation Glutamate Emotion Research (TIGER).Frontiers in human neuroscience · 2020Article
- Multimodal Magnetic Resonance Imaging and Therapeutic Intervention With Yi-nao-jie-yu Decoction in a Rat Model of Post-stroke Depression.Frontiers in psychiatry · 2020Article
- Increased ASL-CBF in the right amygdala predicts the first onset of depression in healthy young first-degree relatives of patients with major depression.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- [Cerebral blood flow measurements in patients with comorbid hypertension and depression using 3D arterial spin labeling].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2019Article
- The Vessels Shaping Mental Health or Illness.The open neurology journal · 2019Article
- Role of polyunsaturated fatty acids in human brain structure and function across the lifespan: An update on neuroimaging findings.Prostaglandins, leukotrienes, and essential fatty acids · 2018Review
- A Comparison of Neuroimaging Abnormalities in Multiple Sclerosis, Major Depression and Chronic Fatigue Syndrome (Myalgic Encephalomyelitis): is There a Common Cause?Molecular neurobiology · 2018Review
- Article
- Microstructural Abnormalities of Basal Ganglia and Thalamus in Bipolar and Unipolar Disorders: A Diffusion Kurtosis and Perfusion Imaging Study.Psychiatry investigation · 2017Article
- How do antidepressants influence the BOLD signal in the developing brain?Developmental cognitive neuroscience · 2017Review
Corrections and comments
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Authors and funding
18 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveAlthough substantial literature has reported regional cerebral blood flow (rCBF) abnormalities in adults with depression, these studies commonly necessitated the injection of radioisotopes into subjects. The recent development of arterial spin labeling (ASL), however, allows noninvasive measurements of rCBF. Currently, no published ASL studies have examined cerebral perfusion in adolescents with depression. Thus, the aim of the present study was to examine baseline cerebral perfusion in adolescent depression using a newly developed ASL technique: pseudocontinuous arterial spin labeling (PCASL).
methodA total of 25 medication-naive adolescents (13-17 years of age) diagnosed with major depressive disorder (MDD) and 26 well-matched control subjects underwent functional magnetic resonance imaging. Baseline rCBF was measured via a novel PCASL method that optimizes tagging efficiency.
resultsVoxel-based whole brain analyses revealed significant frontal, limbic, paralimbic, and cingulate hypoperfusion in the group with depression (p < .05, corrected). Hyperperfusion was also observed within the subcallosal cingulate, putamen, and fusiform gyrus (p < .05, corrected). Similarly, region-of-interest analyses revealed amygdalar and insular hypoperfusion in the group with depression, as well as hyperperfusion in the putamen and superior insula (p < .05, corrected).
conclusionsAdolescents with depression and healthy adolescents appear to differ on rCBF in executive, affective, and motor networks. Dysfunction in these regions may contribute to the cognitive, emotional, and psychomotor symptoms commonly present in adolescent depression. These findings point to possible biomarkers for adolescent depression that could inform early interventions and treatments, and establishes a methodology for using PCASL to noninvasively measure rCBF in clinical and healthy adolescent populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.