ArticleClinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology2013
Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis.
Article in Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02532920 (The Natural History of Atopic Disease in Thai Children and Association With Atopic March), which is not on this map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Natural History of Atopic Disease in Thai Children and Association With Atopic March
Who cites it
32 citing papers in PubMed, 77 citations in OpenAlex.
- Identification of two early life eczema and non-eczema phenotypes with high risk for asthma development.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Trial
- Major Cat Allergen Fel d 4: Structure and Identification of a Cross-Reactive IgE-Epitope-Containing Area.Allergy · 2026Article
- Allergy to Cats: Current Perspectives and Therapeutic Options.Clinical and translational allergy · 2026Review
- Hospital-based patterns of allergen sensitization among 19,787 patients with suspected allergic diseases in Ningbo, China.Frontiers in public health · 2026Article
- Furry Animal Allergy: Lipocalins, Serum Albumins, and Secretoglobins-Cross-Reactivity, Diagnosis, and Management Strategies.Clinical reviews in allergy & immunology · 2025Review
- Vitamin D level is inversely related to allergen sensitization for risking atopic dermatitis in early childhood.The World Allergy Organization journal · 2024Article
- Allergenic Activity of Individual Cat Allergen Molecules.International journal of molecular sciences · 2023Article
- Prevalence of allergen sensitization among children with allergic rhinitis in Changzhou, China: a retrospective observational study.BMC pediatrics · 2023Observational
- Comparison of anaphylaxis epidemiology between urban and suburban pediatric emergency departments.BMC pediatrics · 2023Article
- Increased Expression of Toll-Like Receptor (TLR) 2 and TLR6 on Peripheral Blood Monocytes by Induction of Staphylococcal Enterotoxin B During Exacerbation of Atopic Dermatitis Patients.Clinical, cosmetic and investigational dermatology · 2023Article
- Classification of atopic dermatitis phenotypes according to allergic sensitization by cluster analysis.The World Allergy Organization journal · 2022Article
- Wheeze Recognition Algorithm for Remote Medical Care Device in Children: Validation Study.JMIR pediatrics and parenting · 2021Article
- The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources.The World Allergy Organization journal · 2020Review
- Nasal Provocation Test with Cat and Dog Extracts: Results according to Molecular Components.Pulmonary medicine · 2020Article
- Human toxocariasis and atopy.Parasite (Paris, France) · 2020Article
- Article
- T cells in severe childhood asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2019Review
- Report from the National Institute of Allergy and Infectious Diseases workshop on "Atopic dermatitis and the atopic march: Mechanisms and interventions".The Journal of allergy and clinical immunology · 2019Article
- IgE sensitization in a cohort of adolescents in southern Sweden and its relation to allergic symptoms.Clinical and molecular allergy : CMA · 2019Article
- Dog and Cat Allergies: Current State of Diagnostic Approaches and Challenges.Allergy, asthma & immunology research · 2018Review
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAtopic dermatitis (AD) is common in children; however, persistence of AD with or without asthma is less common. Longitudinal studies remain limited in their ability to characterize how IgE antibody responses evolve in AD, and their relationship with asthma.
objectiveTo use a cross-sectional study design of children with active AD to analyse age-related differences in IgE antibodies and relation to wheeze.
methodsIgE antibodies to food and inhalant allergens were measured in children with active AD (5 months to 15 years of age, n = 66), with and without history of wheeze.
resultsWhereas IgE antibodies to foods persisted at a similar prevalence and titre throughout childhood, IgE antibodies to all aeroallergens rose sharply into adolescence. From birth, the chance of sensitization for any aeroallergen increased for each 12-month increment in age (OR ≥ 1.21, P < 0.01), with the largest effect observed for dust mite (OR = 1.56, P < 0.001). A steeper age-related rise in IgE antibody titre to dust mite, but no other allergen was associated with more severe disease. Despite this, sensitization to cat was more strongly associated with wheeze (OR = 4.5, P < 0.01), and linked to Fel d 1 and Fel d 4, but not Fel d 2. Comparison of cat allergic children with AD to those without, revealed higher IgE levels to Fel d 2 and Fel d 4 (P < 0.05), but not Fel d 1. CONCLUSIONS AND CLINICAL RELEVANCE: Differences in sensitization to cat and dust mite among young children with AD may aid in identifying those at increased risk for disease progression and development of asthma. Early sensitization to cat and risk for wheeze among children with AD may be linked to an increased risk for sensitization to a broader spectrum of allergen components from early life. Collectively, our findings argue for early intervention strategies designed to mitigate skin inflammation in children with AD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.