Trial reportInternational journal of clinical practice2013
Evaluation of an 8-item Severe Impairment Battery (SIB-8) vs. the full SIB in moderate to severe Alzheimer's disease patients participating in a donepezil study.
Trial report in International journal of clinical practice, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Proportion of Women and Reporting of Outcomes by Sex in Clinical Trials for Alzheimer Disease: A Systematic Review and Meta-analysis.JAMA network open · 2021Pooled it
- Occupational social interaction is associated with reduced dementia risk: The Trøndelag Health Study (HUNT).Psychology and aging · 2026Article
- NORRISK 2 score is associated with dementia and MCI-the HUNT study.Frontiers in aging neuroscience · 2026Article
- Better Assessment of Illness Study (BASIL) II for Delirium Severity: Study Design, Variables, and Methods.Journal of geriatric psychiatry and neurology · 2026Article
- Impact of Music Interventions on Depression in Care Home Residents with Dementia: UK Results from Music Interventions for Depression and Dementia in Elderly Care RCT.Geriatrics (Basel, Switzerland) · 2025Article
- Incidence of dementia among individuals 70 years and older in Norway: A HUNT study.Journal of Alzheimer's disease : JAD · 2025Article
- Female Reproductive Factors and Risk of Mild Cognitive Impairment and Dementia: The HUNT Study.The journal of prevention of Alzheimer's disease · 2024Article
- Electroconvulsive therapy for the acute management of severe agitation in dementia (ECT-AD): A modified study protocol.PloS one · 2024Article
- Marital Histories and Associations With Later-Life Dementia and Mild Cognitive Impairment Risk in the HUNT4 70+ Study in Norway.Journal of aging and health · 2023Article
- Blood pressure trajectories over 35 years and dementia risk: A retrospective study: The HUNT study.Frontiers in aging neuroscience · 2022Article
- Current and Future Prevalence Estimates of Mild Cognitive Impairment, Dementia, and Its Subtypes in a Population-Based Sample of People 70 Years and Older in Norway: The HUNT Study.Journal of Alzheimer's disease : JAD · 2021Article
- Non-benzodiazepine hypnotic use for sleep disturbance in people aged over 55 years living with dementia: a series of cohort studies.Health technology assessment (Winchester, England) · 2021Article
- Donepezil plus memantine versus donepezil alone for treatment of concomitant Alzheimer's disease and chronic obstructive pulmonary disease: a retrospective observational study.The Journal of international medical research · 2020Observational
- Associations between depression and anxiety in midlife and dementia more than 30 years later: The HUNT Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Cognitive Profiles on the Severe Impairment Battery Are Similar in Alzheimer Disease and Down Syndrome With Dementia.Alzheimer disease and associated disordersArticle
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 1 country.
Funding
Abstract
aimThe Severe Impairment Battery (SIB), a reliable cognitive measure for evaluating treatment response in advanced Alzheimer's disease (AD), takes approximately 20 min to administer. A recently derived 8-item version of the SIB - the SIB-8 - which takes about 3 min to administer, may represent a more convenient tool for use in clinical practice. The current analyses further explored the SIB-8 scale with respect to its validity and sensitivity.
methodsA post hoc analysis was performed using data from a 24-week trial of donepezil 23 mg/day and 10 mg/day in > 1400 patients with moderate to severe AD [baseline Mini-Mental State Examination (MMSE) score 0-20]. Treatment effects on cognition (patterns of score change) were assessed using the full SIB and SIB-8 in the total study population and subgroups based on concomitant memantine use and baseline MMSE. Internal consistency/agreement and correlations between the SIB and SIB-8 and other clinical end points were evaluated.
resultsAssessment of score changes from baseline to week 24 with donepezil (23 or 10 mg/day) demonstrated comparable patterns of change when using the SIB-8 and the full SIB, despite inherent differences in the total score ranges for the two scales. Internal consistency/agreement between the full SIB and SIB-8 was good (Cronbach's alphas: 0.77-0.95). SIB-8 scores reliably correlated with SIB total scores (r = 0.859, baseline; r = 0.900, week 24; p < 0.0001), as well as MMSE scores (r = 0.7163, baseline; r = 0.7963, week 24; p < 0.0001). Scores on both SIB scales were moderately associated with functional measures at baseline and week 24.
conclusionsIn this post hoc analysis, similar treatment effects were measured by the full SIB and the SIB-8. Very good internal consistency/agreement and strong correlations between the SIB and the more rapid and convenient SIB-8 indicate that the SIB-8 may be a useful and efficient clinical proxy for the full SIB in evaluating treatment response in patients with advanced AD.
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