ArticleLipids in health and disease2013
A novel polymorphism (901G > a) of C5L2 gene is associated with coronary artery disease in Chinese Han and Uyghur population.
Article in Lipids in health and disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Association of C5L2 genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.Oncotarget · 2017Article
- Exome Sequencing in a Family Identifies RECQL5 Mutation Resulting in Early Myocardial Infarction.Medicine · 2016Observational
- Article
- Association of C5aR1genetic polymorphisms with coronary artery disease in a Han population in Xinjiang, China.Diagnostic pathology · 2015Article
- A lack of association between theBiomedical reports · 2015Article
- Association of acylation-stimulating protein and receptor gene polymorphisms with coronary heart disease in Han and Hui populations.International journal of clinical and experimental medicine · 2015Article
- CYP4F2 genetic polymorphisms are associated with coronary heart disease in a Chinese population.Lipids in health and disease · 2014Article
- A novel mutation in C5L2 gene was associated with hyperlipidemia and retinitis pigmentosa in a Chinese family.Lipids in health and disease · 2014Article
- Acylation-stimulating protein is a surrogate biomarker for acute myocardial infarction: Role of statins.Journal of laboratory physiciansArticle
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9 authors.
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Abstract
backgroundC5L2, a G protein-coupled receptor (GPCR), has been demonstrated to be a ligand for acylation-stimulating protein (ASP). The aim of the present study is to evaluate the association of a novel variation (901A > G) of C5L2 gene with coronary artery disease (CAD).
methodsWe identified a novel single nucleotide polymorphism (SNP), (901G > A), in exon 2 using a polymerase chain reaction direct-sequencing method. This nucleotide change causes the amino-acid order from Arginine to glutaminate at codon 300. We analyzed the relationship between this SNP and CAD in two independent case-control studies: one was in a Han population (492 CAD patients and 577 control subjects) and the other was in a Uygur population (319 CAD patients and 554 control subjects).
resultsThe frequency of AG genotype in CAD subjects was less than that in the control subjects not only in Han (1.8% vs 8.6%, P < 0.001, OR = 0.143, 95% CI: 0.068 ~ 0.302) but also in Uygur population (0.9% vs 5.2%, P = 0.001, OR = 0.246, 95% CI: 0.072 ~ 0.837). After adjustment for known CAD risk factors such as hypertension, diabetes, smoking, age and gender, the difference remained significant.
conclusionThe 901G > A polymorphism of C5L2 may be a genetic maker of CAD in the Han and Uygur population in western China.
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