Evidence map›Paper›PMID 24073798›Full record

ReviewThyroid : official journal of the American Thyroid Association2014

Thyrotropin isoforms: implications for thyrotropin analysis and clinical practice.

Joshua M Estrada, Danielle Soldin, Timothy M Buckey, Kenneth D Burman, Offie P Soldin

Abstract readReview
In one paragraph

Review in Thyroid : official journal of the American Thyroid Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 63 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Observational
  5. Review
  6. Article
  7. Review
  8. Thyroid Function across the Lifespan: Do Age-Related Changes Matter?Endocrinology and metabolism (Seoul, Korea) · 2022
    Article
  9. Article
  10. Article
  11. The association between serum TSH concentration whithin the normal range and nutritional status in euthyroid pregnant women at the first trimester of gestation.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2021
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Recent advances in central congenital hypothyroidism.The Journal of endocrinology · 2015
    Review
  19. Reporting Thyroid Function Tests in Pregnancy.The Clinical biochemist. Reviews · 2015
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Joshua M Estrada1 Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University Medical Center , Washington, District of Columbia.
Danielle Soldin
Timothy M Buckey
Kenneth D Burman
Offie P Soldin
Georgetown University · USMedStar Washington Hospital Center · US

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI STEPHEN W BYERS · 1990 to 2026
$71.5M
Hyopthyroidism Treatment in Aging and Thyroid CancerR01AG033867 · NIA · GEORGETOWN UNIVERSITY · PI BURMAN, KENNETH D, JONKLAAS, JACQUELINE · 2010 to 2014
$1.8M
NCI NIH HHS P30CA051008NIA NIH HHS NIHR01AG033867
6 · The paper itself

Abstract

Serum thyrotropin (TSH) is considered the single most sensitive and specific measure of thyroid function in the general population owing to its negative logarithmic association with free triiodothyronine and free thyroxine concentrations. It is therefore often the test of choice for screening, diagnosis, and monitoring of primary hypothyroidism. Serum TSH concentrations can be analyzed quantitatively using third-generation immunoassays, whereas its bioactivity can be measured by TSH activity assays in cell culture. Theoretically, if serum TSH concentrations are directly related to TSH activity, the two tests should yield comparable results. However, on occasion, the results are discordant, with serum concentrations being higher than TSH biological activity. This review focuses on the dissociation between the clinical state and serum TSH concentrations and addresses clinically important aspects of TSH analysis.

Indexed as

Thyroid Function TestsHumansHypothyroidismImmunoassayProtein IsoformsThyrotropinProtein IsoformsThyrotropin

Identifiers

PMID24073798
PMCPMC3949435
OpenAlexW2178118369

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.