ReviewInternational journal of Alzheimer's disease2013
Cholesterol and copper affect learning and memory in the rabbit.
Review in International journal of Alzheimer's disease, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- The Function of Transthyretin Complexes with Metallothionein in Alzheimer's Disease.International journal of molecular sciences · 2020Review
- Critical Review of Exposure and Effects: Implications for Setting Regulatory Health Criteria for Ingested Copper.Environmental management · 2020Review
- The rabbit as a behavioral model system for magnetic resonance imaging.Journal of neuroscience methods · 2018Article
- A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus.Journal of Alzheimer's disease : JAD · 2017Article
- Are microRNAs the Molecular Link Between Metabolic Syndrome and Alzheimer's Disease?Molecular neurobiology · 2016Review
- Molecular events linking cholesterol to Alzheimer's disease and inclusion body myositis in a rabbit model.American journal of neurodegenerative disease · 2016Article
- Dietary cholesterol concentration affects synaptic plasticity and dendrite spine morphology of rabbit hippocampal neurons.Brain research · 2015Article
- The impact of hippocampal lesions on trace-eyeblink conditioning and forebrain-cerebellar interactions.Behavioral neuroscience · 2015Review
- Identification of microRNAs involved in Alzheimer's progression using a rabbit model of the disease.American journal of neurodegenerative disease · 2014Article
- Dietary cholesterol degrades rabbit long term memory for discrimination learning but facilitates acquisition of discrimination reversal.Neurobiology of learning and memory · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
A rabbit model of Alzheimer's disease based on feeding a cholesterol diet for eight weeks shows sixteen hallmarks of the disease including beta amyloid accumulation and learning and memory changes. Although we have shown that feeding 2% cholesterol and adding copper to the drinking water can retard learning, other studies have shown that feeding dietary cholesterol before learning can improve acquisition and feeding cholesterol after learning can degrade long-term memory. We explore the development of this model, the issues surrounding the role of copper, and the particular contributions of the late D. Larry Sparks.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.