ArticlePloS one2013
Reduced sleep-like quiescence in both hyperactive and hypoactive mutants of the Galphaq Gene egl-30 during lethargus in Caenorhabditis elegans.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Article
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- Deregulation of Mitochondrial Calcium Handling Due to Presenilin Loss Disrupts Redox Homeostasis and Promotes Neuronal Dysfunction.Antioxidants (Basel, Switzerland) · 2022Article
- RPamide neuropeptides NLP-22 and NLP-2 act through GnRH-like receptors to promote sleep and wakefulness in C. elegans.Scientific reports · 2020Article
- A wake-active locomotion circuit depolarizes a sleep-active neuron to switch on sleep.PLoS biology · 2020Article
- Genetic sleep deprivation: using sleep mutants to study sleep functions.EMBO reports · 2019Review
- Gap Junctions and NCA Cation Channels Are Critical for Developmentally Timed Sleep and Arousal inGenetics · 2018Article
- Automated detection and manipulation of sleep in C. elegans reveals depolarization of a sleep-active neuron during mechanical stimulation-induced sleep deprivation.Scientific reports · 2018Article
- Genome-Wide Screen for Genes Involved inG3 (Bethesda, Md.) · 2017Article
- High-throughput screening in the C. elegans nervous system.Molecular and cellular neurosciences · 2017Review
- Analysis of the NK2 homeobox geneeLife · 2017Article
- Article
- A Conserved GEF for Rho-Family GTPases Acts in an EGF Signaling Pathway to Promote Sleep-like Quiescence in Caenorhabditis elegans.Genetics · 2016Article
- Distinct Mechanisms Underlie Quiescence during Two Caenorhabditis elegans Sleep-Like States.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Agarose Microchambers for Long-term Calcium Imaging of Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2015Article
- Measurements of behavioral quiescence in Caenorhabditis elegans.Methods (San Diego, Calif.) · 2014Article
- Gene expression changes of Caenorhabditis elegans larvae during molting and sleep-like lethargus.PloS one · 2014Article
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2 authors at 1 institution in 1 country.
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Abstract
Sleep-like states are characterized by massively reduced behavioral activity. Little is known about genetic control of sleep-like behavior. It is also not clear how general activity levels during wake-like behavior influence activity levels during sleep-like behavior. Mutations that increase wake-like activity are generally believed to also increase activity during sleep-like behavior and mutations that decrease wake-like activity are believed to have decreased activity during sleep-like behavior. We studied sleep-like behavior during lethargus in larvae of Caenorhabditis elegans. We looked through a small set of known mutants with altered activity levels. As expected, mutants with increased activity levels typically showed less sleep-like behavior. Among these hyperactive mutants was a gain-of-function mutant of the conserved heterotrimeric G protein subunit Galphaq gene egl-30. We found, however, that an unusual semidominant hypoactive mutant of egl-30 also had reduced sleep-like behavior. While movement was severely reduced and impaired in the semidominant egl-30 mutant, sleep-like behavior was severely reduced: the semidominant egl-30 mutant lacked prolonged periods of complete immobility, reduced spontaneous neural activity less, and reduced responsiveness to stimulation less. egl-30 is a well-known regulator of behavior. Our results suggest that egl-30 controls not only general activity levels, but also differences between wake-like and sleep-like behavior.
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