ArticlePloS one2013
Suppression of DS1 phosphatidic acid phosphatase confirms resistance to Ralstonia solanacearum in Nicotiana benthamiana.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Pathogenicity and virulence ofVirulence · 2026Review
- Suppressed expression of ErbB3-binding protein 1 (EBP1) genes compromised the hypersensitive response cell death inPlant biotechnology (Tokyo, Japan) · 2023Article
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- Fungal effectors versus defense-related genes ofFrontiers in plant science · 2023Review
- GrapevineBiomolecules · 2022Article
- PhcQ mainly contributes to the regulation of quorum sensing-dependent genes, in which PhcR is partially involved, in Ralstonia pseudosolanacearum strain OE1-1.Molecular plant pathology · 2021Article
- Trigalactosyldiacylglycerol 3 protein orthologs are required for basal disease resistance inPlant biotechnology (Tokyo, Japan) · 2021Article
- Recent Advances in Effector-Triggered Immunity in Plants: New Pieces in the Puzzle Create a Different Paradigm.International journal of molecular sciences · 2021Review
- Leaf-to-Whole Plant Spread Bioassay for Pepper andInternational journal of molecular sciences · 2021Article
- Phospholipid signaling pathway in Capsicum chinense suspension cells as a key response to consortium infection.BMC plant biology · 2021Article
- Comparative Transcriptome Profiling Reveals Defense-Related Genes AgainstFrontiers in plant science · 2021Article
- The putative sensor histidine kinase PhcK is required for the full expression of phcA encoding the global transcriptional regulator to drive the quorum-sensing circuit of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2020Article
- Silencing of phosphoinositide dependent protein kinase orthologs reduces hypersensitive cell death inPlant biotechnology (Tokyo, Japan) · 2020Article
- Phosphatidylinositol-phospholipase C2 regulates pattern-triggered immunity in Nicotiana benthamiana.Journal of experimental botany · 2020Article
- The Ralstonia solanacearum effector RipI induces a defence reaction by interacting with the bHLH93 transcription factor in Nicotiana benthamiana.Molecular plant pathology · 2020Article
- Comprehensive Identification of PTI Suppressors in Type III Effector Repertoire Reveals thatInternational journal of molecular sciences · 2019Article
- The type III effector RipB from Ralstonia solanacearum RS1000 acts as a major avirulence factor in Nicotiana benthamiana and other Nicotiana species.Molecular plant pathology · 2019Article
- Contribution of a lectin, LecM, to the quorum sensing signalling pathway of Ralstonia solanacearum strain OE1-1.Molecular plant pathology · 2019Article
- MicroRNA-mediated responses to long-term magnesium-deficiency in Citrus sinensis roots revealed by Illumina sequencing.BMC genomics · 2017Article
- Regulation Involved in Colonization of Intercellular Spaces of Host Plants inFrontiers in plant science · 2017Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotianabenthamiana is susceptible to Ralstonia solanacearum. To analyze molecular mechanisms for disease susceptibility, we screened a gene-silenced plant showing resistance to R. solanacearum, designated as DS1 (Disease suppression 1). The deduced amino acid sequence of DS1 cDNA encoded a phosphatidic acid phosphatase (PAP) 2. DS1 expression was induced by infection with a virulent strain of R. solanacearum in an hrp-gene-dependent manner. DS1 rescued growth defects of the temperature-sensitive ∆lpp1∆dpp1∆pah1 mutant yeast. Recombinant DS1 protein showed Mg(2+)-independent PAP activity. DS1 plants showed reduced PAP activity and increased phosphatidic acid (PA) content. After inoculation with R. solanacearum, DS1 plants showed accelerated cell death, over-accumulation of reactive oxygen species (ROS), and hyper-induction of PR-4 expression. In contrast, DS1-overexpressing tobacco plants showed reduced PA content, greater susceptibility to R. solanacearum, and reduced ROS production and PR-4 expression. The DS1 phenotype was partially compromised in the plants in which both DS1 and NbCoi1 or DS1 and NbrbohB were silenced. These results show that DS1 PAP may affect plant immune responses related to ROS and JA cascades via regulation of PA levels. Suppression of DS1 function or DS1 expression could rapidly activate plant defenses to achieve effective resistance against Ralstonia solanacearum.
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