SynthesisPloS one2013
Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: a systematic review and meta-analysis.
Synthesis in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 74 citations in OpenAlex.
- AI-Assisted Tumor Boundary Delineation via Targeted Ultrasmall Iron Oxide Nanoprobe for High-Contrast HER2-Positive Tumor Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Redefining Margin Assessment in Breast Conservation Surgery: Surgeon-Performed Intraoperative Ultrasound as a Reliable Alternative to Radiologic and Mammographic Assessment.European journal of breast health · 2026Article
- Intraoperative ultrasound in breast-conserving surgery for palpable breast cancer: Association with surgical margins and resection volume.Biomolecules & biomedicine · 2026Article
- [Current evidence on intraoperative ultrasound : A position paper of the German Society for Ultrasound in Medicine (DEGUM)].Chirurgie (Heidelberg, Germany) · 2026Review
- Margin Matters: Advances in Intraoperative Margin Assessment for Breast-Conserving Surgery.Diagnostics (Basel, Switzerland) · 2025Review
- Article
- Article
- Prognostic Impact of Surgical Margin Status on Overall Survival of Patients with Early Breast Cancer: A Retrospective Analysis from the Department for Women's Medicine at Charité - University Hospital Berlin.Geburtshilfe und Frauenheilkunde · 2024Article
- A comparative study of learning curves among general surgery residents for intraoperative ultrasound-guided breast-conserving surgery.Scientific reports · 2024Article
- Reply to Comment on "Recommendations for an Effective and Safe Extreme Oncoplastic Breast Surgery Combining Multiple Techniques".Plastic and reconstructive surgery. Global open · 2023Article
- Comparison of ultrasound guided surgery and radio-guided occult lesions localization (ROLL) for nonpalpable breast cancer excision.Gland surgery · 2023Article
- Ultrasound Guided Intraoperative Wire Localization Under General Anesthesia in Breast-Conserving Surgery.Cureus · 2023Article
- Ultrasound-guided resection for squamous cell carcinoma of the buccal mucosa: A feasibility study.Head & neck · 2023Article
- Review
- Imaging of lumpectomy surface with large field-of-view confocal laser scanning microscope for intraoperative margin assessment - POLARHIS study.Breast (Edinburgh, Scotland) · 2022Article
- Navigated 3D ultrasound-guided resection of high-grade gliomas: A case series and review.Surgical neurology international · 2022Article
- The Beneficial Impact of Intraoperative Ultrasound on Resection Margin Status during Breast Conserving Surgery.International journal of surgical oncology · 2022Article
- Implementation of Intraoperative Ultrasound Localization for Breast-Conserving Surgery in a Large, Integrated Health Care System is Feasible and Effective.Annals of surgical oncology · 2021Article
- Precision Breast-Conserving Surgery With Microwave Ablation Guidance: A Pilot Single-Center, Prospective Cohort Study.Frontiers in oncology · 2021Article
- Ultrasound Guided Optoacoustic Tomography in Assessment of Tumor Margins for Lumpectomies.Translational oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMargin status is one of the most important predictors of local recurrence after breast conserving surgery (BCS). Intraoperative ultrasound guidance (IOUS) has the potential to improve surgical accuracy for breast cancer. The purpose of the present meta-analysis was to determine the efficacy of IOUS in breast cancer surgery and to compare the margin status to that of the more traditional Guide wire localization (GWL) or palpation-guidance.
methodsWe searched the database of PubMed for prospective and retrospective studies about the impact of IOUS on margin status of breast cancer, and a meta-analysis was conducted.
resultsOf the 13 studies included, 8 were eligible for the impact of IOUS on margin status of non-palpable breast cancers, 4 were eligible for palpable breast cancers, and 1 was for both non-palpable and palpable breast cancers. The rate of negative margins of breast cancers in IOUS group was significantly higher than that in control group without IOUS (risk ratio (RR) = 1.37, 95% confidence interval (CI) = 1.18-1.59 from 7 prospective studies, odds ratio (OR) = 2.75, 95% CI = 1.66-4.55 from 4 retrospective studies). For non-palpable breast cancers, IOUS-guidance enabled a significantly higher rate of negative margins than that of GWL-guidance (RR = 1.26, 95% CI = 1.09-1.46 from 6 prospective studies; OR = 1.45, 95% CI = 0.86-2.43 from 2 retrospective studies). For palpable breast cancers, relative to control group without IOUS, the RR for IOUS associated negative margins was 2.36 (95% CI = 1.26-4.43) from 2 prospective studies, the OR was 2.71 (95% CI = 1.25-5.87) from 2 retrospective studies.
conclusionThis study strongly suggests that IOUS is an accurate method for localization of non-palpable and palpable breast cancers. It is an efficient method of obtaining high proportion of negative margins and optimum resection volumes in patients undergoing BCS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.