ArticlePesticide biochemistry and physiology2013
Indoxacarb, Metaflumizone, and Other Sodium Channel Inhibitor Insecticides: Mechanism and Site of Action on Mammalian Voltage-Gated Sodium Channels.
Article in Pesticide biochemistry and physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 57 citations in OpenAlex.
- Residue Dynamics of Metaflumizone in Tomatoes and Peppers Using LC-MS/MS: Pre-Harvest Intervals and Dietary Risk Assessment.ACS omega · 2025Article
- Pesticidal efficacy of some innovative phenyl benzoate-based heterocycles againstRSC advances · 2025Article
- Mechanisms and Genetic Drivers of Resistance of Insect Pests to Insecticides and Approaches to Its Control.Toxics · 2025Review
- Taurine Mitigates Metaflumizone-Induced Hepatonephrotoxicity in Rats by Inhibiting Oxidative Stress, Inflammation, and Apoptosis.Journal of biochemical and molecular toxicology · 2025Article
- Computational investigation of behavioral toxicity syndromes (BTS) of synthetics halosubstituted semicarbazones.In silico pharmacology · 2025Article
- Article
- On the Question of the Formation of Nitro-Functionalized 2,4-Pyrazole Analogs on the Basis of Nitrylimine Molecular Systems and 3,3,3-Trichloro-1-Nitroprop-1-Ene.Molecules (Basel, Switzerland) · 2022Article
- Insecticide Rotation and Adaptive Fitness Cost Underlying Insecticide Resistance Management for Spodoptera frugiperda (Lepidoptera: Noctuidae).Neotropical entomology · 2020Article
- Molecular Mechanism of Action and Selectivity of Sodium Ch annel Blocker Insecticides.Current medicinal chemistry · 2017Review
- The Receptor Site and Mechanism of Action of Sodium Channel Blocker Insecticides.The Journal of biological chemistry · 2016Article
- Mutations in the transmembrane helix S6 of domain IV confer cockroach sodium channel resistance to sodium channel blocker insecticides and local anesthetics.Insect biochemistry and molecular biology · 2015Article
- Voltage-Gated Sodium Channels as Insecticide Targets.Advances in insect physiology · 2014Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Sodium channel inhibitor (SCI) insecticides were discovered almost four decades ago but have only recently yielded important commercial products (eg., indoxacarb and metaflumizone). SCI insecticides inhibit sodium channel function by binding selectively to slow-inactivated (non-conducting) sodium channel states. Characterization of the action of SCI insecticides on mammalian sodium channels using both biochemical and electrophysiological approaches demonstrates that they bind at or near a drug receptor site, the "local anesthetic (LA) receptor." This mechanism and site of action on sodium channels differentiates SCI insecticides from other insecticidal agents that act on sodium channels. However, SCI insecticides share a common mode of action with drugs currently under investigation as anticonvulsants and treatments for neuropathic pain. In this paper we summarize the development of the SCI insecticide class and the evidence that this structurally diverse group of compounds have a common mode of action on sodium channels. We then review research that has used site-directed mutagenesis and heterologous expression of cloned mammalian sodium channels in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.