ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2014
Inhibition of protein translation as a novel mechanism for prostaglandin E2 regulation of cell functions.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
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- Reimagining Fibrosis Research, Outcomes, and Therapeutics Through the Lens of Resolution.Seminars in respiratory and critical care medicine · 2025Review
- Obesity Inhibits Alveolar Macrophage Responses to Pseudomonas aeruginosa Pneumonia via Upregulation of Prostaglandin E2 in Male, but Not Female, Mice.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- The imbalance of PGD2-DPs pathway is involved in the type 2 diabetes brain injury by regulating autophagy.International journal of biological sciences · 2021Article
- PGELife science alliance · 2020Article
- Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling.American journal of respiratory and critical care medicine · 2020Article
- Antibiotic pretreatment alleviates liver transplant damage in mice and humans.The Journal of clinical investigation · 2019Article
- Special Delivery: A New Package for an Old Antifibrotic Mediator.American journal of respiratory cell and molecular biology · 2019Article
- Distinct PKA regulatory subunits mediate PGEAmerican journal of physiology. Lung cellular and molecular physiology · 2017Article
- Nutritional status-dependent endocannabinoid signalling regulates the integration of rat visceral information.The Journal of physiology · 2017Article
- Reversal of the Transcriptome by Prostaglandin E2 during Myofibroblast Dedifferentiation.American journal of respiratory cell and molecular biology · 2016Article
- Prostaglandin E2 reduces Toll-like receptor 4 expression in alveolar macrophages by inhibition of translation.American journal of respiratory cell and molecular biology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Prostaglandin E2 (PGE2) regulates numerous biological processes by modulating transcriptional activation, epigenetic control, proteolysis, and secretion of various proteins. Scar formation depends on fibroblast elaboration of matrix proteins such as collagen, and this process is strongly suppressed by PGE2 through activation of cAMP-dependent protein kinase A (PKA). However, the actual mechanism by which PGE2-PKA signaling inhibits collagen expression in fibroblasts has never been delineated, and that was the objective of this study. PGE2 unexpectedly induced a rapid reduction in procollagen I protein expression in adult lung fibroblasts, with a half-maximum effect at 1.5 h. This effect reflected its inhibition of translation rather than transcription. Global protein synthesis was also inhibited by PGE2. This action was mediated by PKA and involved both activation of ribosomal protein (rpS6) and suppression of mammalian target of rapamycin (mTOR). Similar effects of PGE2 were demonstrated in mouse peritoneal macrophages (PMs). These findings identify inhibition of translation as a new mechanism by which PGE2 regulates cellular function and a novel example of translational inhibition mediated by opposing actions on two distinct translational control pathways. Translational inhibition would be expected to contribute to dynamic alterations in cell function that accompany the changing PGE2 levels observed in disease states and with various pharmacotherapies.
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Registered trials
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