ReviewJournal of neural transmission. General section1990
Urinary MHPG sulfate as a marker of central norepinephrine metabolism: a commentary.
Review in Journal of neural transmission. General section, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 25 citations in OpenAlex.
- Decreased urinary excretion of norepinephrine and dopamine in autonomic synucleinopathies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025Article
- Diagnostic Performance of Sex-Specific Modified Metabolite Patterns in Urine for Screening of Prediabetes.Frontiers in endocrinology · 2022Article
- A Convenient Method for Extraction and Analysis with High-Pressure Liquid Chromatography of Catecholamine Neurotransmitters and Their Metabolites.Journal of visualized experiments : JoVE · 2018Article
- The Efficacy of Intermittent Walking in Water on the Rate of MHPG Sulfate and the Severity of Depression.Iranian journal of psychiatry and behavioral sciences · 2011Article
- A phase 1 trial of pharmacologic interactions between transdermal selegiline and a 4-hour cocaine infusion.BMC clinical pharmacology · 2009Article
- A simplified routine assay for urinary 3-methoxy-4-hydroxyphenylglycol.Journal of neural transmission (Vienna, Austria : 1996) · 1997Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Measurement of total (free + conjugated) 3 methoxy-4-hydroxyphenylglycol (MHPG) in urine has long been used to assess the metabolism of central norepinephrine (NE). However, available data indicate that total MHPG is not a sensitive marker because the portion of urinary MHPG which derives from brain NE is less than was previously assumed. Several arguments support the view that central MHPG excretion is best represented by the urinary MHPG sulfate fraction. Accordingly, a new strategy has been introduced in last years, involving the separate determination of sulfate and glucuronide conjugates of MHPG as respective markers of central and peripheral NE metabolism. Various biochemical and pharmacological data obtained in healthy subjects and in patients with mental diseases support this hypothesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.