SynthesisMolecular biology reports2013
Functional polymorphism rs4072037 in MUC1 gene contributes to the susceptibility to gastric cancer: evidence from pooled 6,580 cases and 10,324 controls.
Synthesis in Molecular biology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy.Human reproduction (Oxford, England) · 2023Pooled it
- Novel role of prostate cancer risk variant rs7247241 on PPP1R14A isoform transition through allelic TF binding and CpG methylation.Human molecular genetics · 2022Article
- Human genomics of the humoral immune response against polyomaviruses.Virus evolution · 2021Article
- Association between theJournal of gastric cancer · 2020Article
- Family-based exome sequencing combined with linkage analyses identifies rare susceptibility variants of MUC4 for gastric cancer.PloS one · 2020Article
- Review
- Association of MUC1 rs4072037 Functional Polymorphism and Cancer Risk: Evidence from 12551 Cases and 13436 Controls.Journal of Cancer · 2018Article
- Genetic variants of mucins: unexplored conundrum.Carcinogenesis · 2017Review
- Article
- Molecular alterations in gastric cancer with special reference to the early-onset subtype.World journal of gastroenterology · 2016Review
- Polymorphisms in mucin genes in the development of gastric cancer.World journal of gastrointestinal oncology · 2015Review
- Challenges of deciphering gastric cancer heterogeneity.World journal of gastroenterology · 2015Review
- Associations of genetic variants in the PSCA, MUC1 and PLCE1 genes with stomach cancer susceptibility in a Chinese population.PloS one · 2015Article
- Genetic variants at 8q24 are associated with risk of esophageal squamous cell carcinoma in a Chinese population.Cancer science · 2014Article
- Mucin 1 gene (MUC1) and gastric-cancer susceptibility.International journal of molecular sciences · 2014Article
- Role of gene polymorphisms in gastric cancer and its precursor lesions: current knowledge and perspectives in Latin American countries.World journal of gastroenterology · 2014Review
- Common genetic variants at 1q22 and 10q23 and gastric cancer susceptibility in a Korean population.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- The effect of MUC1 rs4072037 functional polymorphism on cancer susceptibility: evidence from published studies.PloS one · 2014Article
- MUC1 gene polymorphism rs4072037 and susceptibility to gastric cancer: a meta-analysis.SpringerPlus · 2014Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genome-wide association studies have reported a promising association of rs4072037 with gastric cancer (GC). This variant was associated with altered physiological function of MUC1 possibly by modulating promoter activity and alternative splicing of MUC1. However, the association results were inconclusive and estimate of the effect of this variant was not well evaluated. A meta-analysis by systematically reviewing relevant reports may facilitate to address these concerns. Association studies involving MUC1 rs4072037 polymorphism and GC risk were identified up to June 30, 2012. Odds ratio (OR) and 95 % confidence interval (CI) in additive model were estimated or extracted from each study. The pooled effect size was quantitatively synthesized using meta-analysis. Heterogeneity between studies was measured by the Q test and I (2) statistic, and publication bias was evaluated by a funnel plot and the Egger's test. A total of 10 independent case-control studies including 6,580 GC cases and 10,324 controls were included in this meta-analysis. Eight of the ten studies were Asian ethnicity and two European. The G allele of MUC1 rs4072037 was significantly associated with a decreased risk of GC (OR = 0.72, 95 % CI 0.68-0.77; P = 7.82 × 10(-25)), as compared with A allele. Stratification for different ethnicity, tumor localization or type showed similar results. These findings represent important evidence for association of MUC1 rs4072037 variant with GC risk, and also provide a relatively reliable estimate of effect size. MUC1 is a strong candidate as a susceptibility gene of GC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.