Evidence map›Paper›PMID 24072604›Full record

ReviewCurrent rheumatology reports2013

Homeostatic mechanisms in articular cartilage and role of inflammation in osteoarthritis.

Xavier Houard, Mary B Goldring, Francis Berenbaum

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current rheumatology reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 185 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
185citing papers in PubMed, 2 pooled it
19.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

185 citing papers in PubMed, 2 syntheses or guidelines pooled it, 338 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Human Knee as an Organ: Joint Tissue Collection, Processing, and Scoring for Multimodal Analyses.Laboratory investigation; a journal of technical methods and pathology · 2026
    Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. 2050: An Arthroplasty Odyssey.Healthcare (Basel, Switzerland) · 2025
    Article
  17. Review
  18. Article
  19. Review
  20. Review

125 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Xavier HouardUPMC, Univ Paris 06, UR4 "Ageing, Stress and Inflammation", Labex Transimmunom, Inflammation- Immunopathology-Biotherapy department (I2B), F-75252, Cedex 5, Paris, France.
Mary B Goldring
Francis Berenbaum
Transgene (France) · FRHospital for Special Surgery · US

Funding

Defining Common Molecular Parameters For Onset and Progression of OsteoarthritisRC4AR060546 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI GOLDRING, MARY B, LI, YEFU · 2010 to 2010
$4.1M
Role of ESE1 Regulation of Type II Collagen in CartilageR01AG022021 · NIA · HOSPITAL FOR SPECIAL SURGERY · PI GOLDRING, MARY B · 2002 to 2014
$3.4M
NIAMS NIH HHS RC4 AR060546NIAMS NIH HHS RC4-AR060546NIA NIH HHS R01 AG022021NIA NIH HHS R01-AG022021
6 · The paper itself

Abstract

Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its cause (aging, genetic predisposition, trauma or metabolic disorder) induces profound phenotypic modifications of chondrocytes, which then promote the synthesis of a subset of factors that induce cartilage damage and target other joint tissues. Interestingly, among these factors are numerous components of the inflammatory pathways. Chondrocytes produce cytokines, chemokines, alarmins, prostanoids, and adipokines and express numerous cell surface receptors for cytokines and chemokines, as well as Toll-like receptors. These receptors activate intracellular signaling pathways involved in inflammatory and stress responses of chondrocytes in OA joints. This review focuses on mechanisms responsible for the maintenance of cartilage homeostasis and highlights the role of inflammatory processes in OA progression.

Indexed as

AdipokinesCartilage, ArticularChemokinesHomeostasisHumansInflammationMechanotransduction, CellularOsteoarthritisSignal TransductionToll-Like ReceptorsAdipokinesChemokinesToll-Like Receptors

Identifiers

PMID24072604
PMCPMC3989071
OpenAlexW2028212402

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.