ArticleEuropace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology2014
Common SCN10A variants modulate PR interval and heart rate response during atrial fibrillation.
Article in Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 26 citations in OpenAlex.
- Common and rare variants in SCN10A modulate the risk of atrial fibrillation.Circulation. Cardiovascular genetics · 2015Trial
- Impact of SCN10A Polymorphism on Abdominal Pain Perception and Visceral Hypoalgesia in Crohn's Disease and Ulcerative Colitis.Clinical and translational gastroenterology · 2024Article
- Blocking NaBMC cardiovascular disorders · 2024Article
- Common variants in SCN10A gene associated with Brugada syndrome.Human molecular genetics · 2021Article
- Blockade of NaFrontiers in cardiovascular medicine · 2021Article
- The Role of Voltage-Gated Sodium Channel 1.8 in the Effect of Atropine on Heart Rate: Evidence From a Retrospective Clinical Study and Mouse Model.Frontiers in pharmacology · 2020Article
- Absence of Functional NaCardiovascular drugs and therapy · 2019Article
- Functional characterization of SCN10A variants in several cases of sudden unexplained death.Forensic science international · 2019Article
- Deleterious protein-altering mutations in the SCN10A voltage-gated sodium channel gene are associated with prolonged QT.Clinical genetics · 2018Article
- Homozygosity for the SCN10A Polymorphism rs6795970 Is Associated With Hypoalgesic Inflammatory Bowel Disease Phenotype.Frontiers in medicine · 2018Article
- Association of common and rare variants of SCN10A gene with sudden unexplained nocturnal death syndrome in Chinese Han population.International journal of legal medicine · 2017Article
- Neuronal Nav1.8 Channels as a Novel Therapeutic Target of Acute Atrial Fibrillation Prevention.Journal of the American Heart Association · 2016Article
- A SCN10A SNP biases human pain sensitivity.Molecular pain · 2016Article
- Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.Cardiovascular research · 2015Article
- Recent genetic discoveries implicating ion channels in human cardiovascular diseases.Current opinion in pharmacology · 2014Review
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8 authors at 1 institution in 1 country.
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Abstract
aimsSCN10A encodes the sodium channel Nav1.8 implicated by genome-wide association studies as a modulator of atrioventricular conduction (PR interval). In a cohort of patients with atrial fibrillation (AF), we examined whether there was an association between common variants in SCN10A and both the PR interval during normal sinus rhythm and the heart rate response during AF. METHODS AND
resultsPatients prospectively enrolled in the Vanderbilt AF registry with electrocardiograms in normal sinus rhythm and/or AF within 1 year of enrollment were genotyped for two common SCN10A variants rs6795970 and rs12632942. Both variants were associated with the PR interval duration in a gene-dose effect on unadjusted analysis; after adjustment for the covariates age, gender, body mass index, hypertension, congestive heart failure, and medication usage, the association remained for rs6795970 only (P = 0.012, partial R(2) = 0.0139). On unadjusted analysis, heart rate response during AF was associated with rs6795970 (P = 0.035, partial R(2) = 0.015), but not with rs12632942 (P = 0.89), and neither association was significant after adjustment for covariates.
conclusionThe common variant rs6795970 in SCN10A is associated with the PR interval duration among healthy patients and those with AF. In addition, this single nucleotide polymorphism trended towards an association with heart rate response during AF indicating the importance of this common SCN10A polymorphism as a marker of atrioventricular conduction.
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