Evidence map›Paper›PMID 24072390›Full record

ArticleJournal of materials science. Materials in medicine2014

The effect of tenocyte/hyaluronic acid therapy on the early recovery of healing Achilles tendon in rats.

Jen-I Liang, Ping-Chia Lin, Meng-Yi Chen, Tsung-Hsun Hsieh, Jia-Jin Jason Chen, Ming-Long Yeh

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of materials science. Materials in medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Article
  3. Biomimetic Scaffolds for Tendon Tissue Regeneration.Biomimetics (Basel, Switzerland) · 2023
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Current Progress in Tendon and Ligament Tissue Engineering.Tissue engineering and regenerative medicine · 2019
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Article
  16. Hyaluronic acid and tendon lesions.Muscles, ligaments and tendons journal
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jen-I LiangDepartment of Biomedical Engineering, National Cheng Kung University, No. 1, University Road, Tainan, 701, Taiwan.
Ping-Chia Lin
Meng-Yi Chen
Tsung-Hsun Hsieh
Jia-Jin Jason Chen
Ming-Long Yeh
National Cheng Kung University · TWTaipei Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to explore the potential for a better recovery outcome for the Achilles tendon at an early healing stage when a mixed biomaterial-tenocyte injection is used. The experimental animals underwent single limb Achilles tendon transection followed by suturing repair. A solution of either hyaluronic acid with or without tenocytes or normal saline was randomly chosen to be injected around the injury site after surgery. To obtain the comprehensive recovery condition of the rats on different management protocols, the animals were evaluated histologically, mechanically, and functionally. A significant difference in the recovery condition was found in the injured tendon injected with the hyaluronic acid solution with tenocytes compared with the other groups. Tendon stiffness and the locomotion abilities of the rats with healing Achilles tendons were improved in the hyaluronic acid with tenocyte transplantation group. The acceleration of the inflammatory phase in rats with the hyaluronic acid with tenocyte injections might be the major reason for the better functional outcomes.

Indexed as

Cell TransplantationAchilles TendonAnimalsBiomechanical PhenomenaDisease Models, AnimalGaitHyaluronic AcidMaleMaterials TestingRatsRats, Sprague-DawleyRuptureTendon InjuriesWound HealingHyaluronic Acid

Identifiers

PMID24072390
OpenAlexW2019616190

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.