Trial reportEuropean journal of applied physiology2013
Effect of adiposity on insulin action after acute and chronic resistance exercise in non-diabetic women.
Trial report in European journal of applied physiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 5 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Effects of Moderate-Frequency Resistance Training on Cardiometabolic Risk Factors in Adults With Overweight or Obesity: A Systematic Review and Meta-Analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026Pooled it
- The role of resistance training in improving beta-cell function in type 2 diabetes: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Effect of nine different exercise interventions on insulin sensitivity in diabetic patients: a systematic review and mesh meta-analysis.Frontiers in endocrinology · 2025Pooled it
- The Effect of Resistance Training in Healthy Adults on Body Fat Percentage, Fat Mass and Visceral Fat: A Systematic Review and Meta-Analysis.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- The Effect of Resistance Training in Women on Dynamic Strength and Muscular Hypertrophy: A Systematic Review with Meta-analysis.Sports medicine (Auckland, N.Z.) · 2020Pooled it
- Improvements in glucose metabolism after high-, but not low-, volume strength exercise in individuals with obesity are associated with baseline insulin resistance: a secondary analysis from a randomized clinical trial.European journal of applied physiology · 2026Trial
- Exercise mode influences post-exercise glucose sensitivity and insulin clearance in young, healthy males and females in a sex-dependent manner: A randomized control trial.Physiological reports · 2022Trial
- The effects of aerobic, resistance, and combination training on insulin sensitivity and secretion in overweight adults from STRRIDE AT/RT: a randomized trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Trial
- Physical activity and exercise within the context of obesity treatment: Enhancing health beyond weight loss.Journal of sport and health science · 2025Review
- Article
- Effects of the association of different volumes of strength training with photobiomodulation therapy on insulin resistance: A protocol for a randomized, triple-blind, placebo-controlled trial.Contemporary clinical trials communications · 2022Article
- Enhanced skeletal muscle insulin sensitivity after acute resistance-type exercise is upregulated by rapamycin-sensitive mTOR complex 1 inhibition.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObesity may attenuate metabolic health improvements following lifestyle interventions. However, the effect of adiposity on insulin action following resistance exercise in young non-diabetic women is unknown. The purpose of this study was to test the hypothesis that adiposity attenuates improvements in insulin sensitivity and glucose-stimulated insulin secretion (INS0-60/GLC0-60) after both acute resistance exercise (ARE) and progressive training (PRT).
methodsTwenty-six young non-diabetic women (21.2 ± 0.7 years) were randomly assigned to control (C; n = 7; BF 40.1 ± 2.1 %) or exercise groups: normal body fat (NBF; n = 8; BF 29.9 ± 2.3 %) and high body fat (HBF; n = 12; BF 48.2 ± 1.4 %). Acute whole-body exercises were performed at 60 % of 1-RM for three sets of 8-12 repetitions, and PRT was performed 3 days/week for 7 weeks. A 75 g OGTT was conducted before and after ARE and PRT to estimate insulin sensitivity (Matsuda index) and INS0-60/GLC0-60. Insulin area under the curve (AUC) was calculated using the trapezoidal model.
resultsARE had no statistical effect on insulin action across groups. Strength and fat-free mass (via DXA) increased after PRT in both NBF and HBF (p < 0.05), but only HBF women decreased BF (p < 0.01). HBF women were less insulin sensitive at baseline compared to NBF women (p < 0.05). Insulin sensitivity increased 95 % and INS0-60/GLC0-60 decreased 32 % following PRT in NBF, but not HBF or C (p < 0.05). After training, enhanced insulin sensitivity was inversely related to decreased INS0-60/GLC0-60 (r = -0.71, p < 0.001), fasting insulin (r = -0.71, p < 0.001), and insulin AUC (r = -0.85, p < 0.001).
conclusionSeven weeks of PRT increases insulin sensitivity and reduces glucose-stimulated insulin secretion in NBF, but not HBF women. Obesity attenuates exercise-induced improvements in glucose regulation in young non-diabetic women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.