ArticleInvestigative ophthalmology & visual science2013
Imaging of vascular wall fine structure in the human retina using adaptive optics scanning laser ophthalmoscopy.
Article in Investigative ophthalmology & visual science, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 118 citations in OpenAlex.
- Retinal Arteriolar Morphometry Based on Full Width at Half Maximum Analysis of Spectral-Domain Optical Coherence Tomography Images.PloS one · 2015Trial
- Multimodal retinal vessel analysis in CADASIL patients.PloS one · 2014Trial
- Characterization of Leukocyte Crawling in the Living Human Retina Using Adaptive Optics Scanning Light Ophthalmoscopy.Investigative ophthalmology & visual science · 2026Article
- Quantitative Retinal Vascular Imaging Using Flood-Illuminated Adaptive Optics in Eyes with Lens Opacities.Bioengineering (Basel, Switzerland) · 2026Article
- Validation of Deep Capillary Plexus OCTA Metrics as Predictors of Diabetic Retinopathy Complications: A One-Year Longitudinal Study.Research square · 2026Article
- Single wavelength, dual temporal offset module for AOSLO systems.Biomedical optics express · 2026Article
- Quantifying Capillary Pericytes In Vivo Links Them to Retinal Vascular Leakage and Potentially Albuminuria: A Pilot Study in Diabetes.Arteriosclerosis, thrombosis, and vascular biology · 2025Article
- Revealing neurovascular coupling at a high spatial and temporal resolution in the living human retina.Science advances · 2025Article
- Doppler OCT verifies pulsation-induced anisotropic vessel lumen dynamics in the human retina.Optics letters · 2025Article
- Improvements on speed, stability and field of view in adaptive optics OCT for anterior retinal imaging using a pyramid wavefront sensor.Biomedical optics express · 2024Article
- Macular vascular and photoreceptor changes for diabetic macular edema at early stage.Scientific reports · 2024Article
- Compact Linear Flow Phantom Model for Retinal Blood-Flow Evaluation.Diagnostics (Basel, Switzerland) · 2024Article
- Hypertension Likely Drives Arteriolar Wall Thickening in Preclinical Diabetic Retinopathy While Diabetes Drives Wall Thickness in Clinical Retinopathy.Translational vision science & technology · 2024Article
- Changes to the shape, orientation and packing of red cells as a function of retinal capillary size.Biomedical optics express · 2024Article
- Imaging the Retinal Vascular Mural Cells In Vivo: Elucidating the Timeline of Their Loss in Diabetic Retinopathy.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- Adaptive vessel tracing and segmentation in OCT enables the robust detection of wall-to-lumen ratio abnormalities in 5xFAD mice.Biomedical optics express · 2023Article
- Retinal Arteriolar Wall Remodeling in Diabetes Captured With AOSLO.Translational vision science & technology · 2023Article
- Non-Invasive Retinal Blood Vessel Wall Measurements with Polarization-Sensitive Optical Coherence Tomography for Diabetes Assessment: A Quantitative Study.Biomolecules · 2023Article
- Wide-Field Three-Dimensional Depth-Invariant Cellular-Resolution Imaging of the Human Retina.Small (Weinheim an der Bergstrasse, Germany) · 2023Article
- Evolution of adaptive optics retinal imaging [Invited].Biomedical optics express · 2023Review
16 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo improve the ability to image the vascular walls in the living human retina using multiply-scattered light imaging with an adaptive optics scanning laser ophthalmoscope (AOSLO).
methodsIn vivo arteriolar wall imaging was performed on eight healthy subjects using the Indiana AOSLO. Noninvasive imaging of vascular mural cells and wall structure were performed using systematic control of the position of a 10× Airy disk confocal aperture. Retinal arteries and arterioles were divided into four groups based on their lumen diameters (group 1: ≥100 μm; group 2: 50-99 μm; group 3: 10-49 μm; group 4: <10 μm).
resultsFine structure of retinal vasculature and scattering behavior of erythrocytes were clearly visualized in all eight subjects. In group 1 vessels the mural cells were flatter and formed the outer layer of regularly spaced cells of a two (or more) layered vascular wall. In the vessels of groups 2 and 3, mural cells were visualized as distinct cells lying along the lumen of the blood vessel, resulting in a wall of irregular thickness. Vascular wall components were not readily identified in group 4 vessels.
conclusionsOur results show that retinal vascular mural cells and wall structure can be readily resolved in healthy subjects using AOSLO with multiply scattered light imaging for retinal vessels with a lumen diameter greater than or equal to 10 μm. Our noninvasive imaging approach allows direct assessment of the cellular structure of the vascular wall in vivo with potential applications in retinal vascular diseases such as diabetes and hypertension.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.