ArticleChemical communications (Cambridge, England)2013
A fluorescent peroxidase probe increases the sensitivity of commercial ELISAs by two orders of magnitude.
Article in Chemical communications (Cambridge, England), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed.
- Highly Sensitive Measurement of Horseradish Peroxidase Using Surface-Enhanced Raman Scattering of 2,3-Diaminophenazine.Molecules (Basel, Switzerland) · 2024Article
- Nanocellulose-Based Passivated-Carbon Quantum Dots (P-CQDs) for Antimicrobial Applications: A Practical Review.Polymers · 2023Review
- Bacterial Peroxidase on Electrochemically Reduced Graphene Oxide for Highly Sensitive HChembiochem : a European journal of chemical biology · 2022Article
- A CRISPR-based ultrasensitive assay detects attomolar concentrations of SARS-CoV-2 antibodies in clinical samples.Nature communications · 2022Article
- Study on Factors Affecting the Performance of a CRISPR/Cas-Assisted New Immunoassay: Detection of Salivary Insulin as an Example.Frontiers in bioengineering and biotechnology · 2021Article
- Lanthanide-Doped Upconversion-Linked Immunosorbent Assay for the Sensitive Detection of Carbohydrate Antigen 19-9.Frontiers in chemistry · 2020Article
- Enzyme-linked oligonucleotide hybridization assay for direct oligo measurement in blood.Biology methods & protocols · 2019Article
- Improvement of enzyme-linked immunosorbent assay for the multicolor detection of biomarkers.Chemical science · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The low detection sensitivity of enzyme linked immunosorbent assays (ELISAs) is a central problem in science and limits progress in multiple areas of biology and medicine. In this report we demonstrate that the hydrocyanines, a family of fluorescent reactive oxygen species (ROS) probes, can act as turn on fluorescent horseradish peroxidase (HRP) probes and thereby increase the sensitivity of conventional ELISAs by two orders of magnitude.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.