ArticleNature genetics2013
Complex genetics of drug resistance in Mycobacterium tuberculosis.
Article in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Comparative Proteomic Analyses of Avirulent, Virulent, and Clinical Strains of Mycobacterium tuberculosis Identify Strain-specific Patterns.The Journal of biological chemistry · 2016Article
- NR1D1 ameliorates Mycobacterium tuberculosis clearance through regulation of autophagy.Autophagy · 2015Article
- The road to drug resistance in Mycobacterium tuberculosis.Genome biology · 2014Article
- Translating genomics research into control of tuberculosis: lessons learned and future prospects.Genome biology · 2014Review
- KvarQ: targeted and direct variant calling from fastq reads of bacterial genomes.BMC genomics · 2014Article
- Insights into battles between Mycobacterium tuberculosis and macrophages.Protein & cell · 2014Review
- 1,4-azaindole, a potential drug candidate for treatment of tuberculosis.Antimicrobial agents and chemotherapy · 2014Article
- Whole-genome sequencing to control antimicrobial resistance.Trends in genetics : TIG · 2014Review
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- MUBII-TB-DB: a database of mutations associated with antibiotic resistance in Mycobacterium tuberculosis.BMC bioinformatics · 2014Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three new studies have used whole-genome sequencing of M. tuberculosis to demonstrate unexpected complexity in the modern evolution of drug-resistant tuberculosis, and a fourth study suggests a close evolutionary relationship between the pathogen and its human host over a period of 70,000 years. Collectively, the observations in these studies suggest that future strategies to tackle drug-resistant tuberculosis must integrate host genetics with detailed strain epidemiology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.