ReviewExperimental neurology2014
Modeling Parkinson's disease in monkeys for translational studies, a critical analysis.
Review in Experimental neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 70 citations in OpenAlex.
- Calbindin and Girk2/Aldh1a1 define resilient vs vulnerable dopaminergic neurons in a primate Parkinson's disease model.NPJ Parkinson's disease · 2024Article
- Construct, Face, and Predictive Validity of Parkinson's Disease Rodent Models.International journal of molecular sciences · 2024Review
- The importance of social behavior in nonhuman primate studies of aging: A mini-review.Neuroscience and biobehavioral reviews · 2023Review
- Dysphagia in Parkinson Disease: Part II-Current Treatment Options and Insights from Animal Research.Current physical medicine and rehabilitation reports · 2023Article
- Remote photobiomodulation targeted at the abdomen or legs provides effective neuroprotection against parkinsonian MPTP insult.The European journal of neuroscience · 2023Article
- Quantification of early gait development: Expanding the application of Catwalk technology to an infant rhesus macaque model.Journal of neuroscience methods · 2023Article
- Current Knowledge on the Background, Pathophysiology and Treatment of Levodopa-Induced Dyskinesia-Literature Review.Journal of clinical medicine · 2021Review
- Striatal Oscillations in Parkinsonian Non-Human Primates.Neuroscience · 2020Article
- Impaired Hand Dexterity Function in a Non-human Primate Model with Chronic Parkinson's Disease.Experimental neurobiology · 2020Article
- A pilot study on assessment of locomotor behavior using a video tracking system in minipigs.Experimental animals · 2020Article
- Quantitative whole-brain 3D imaging of tyrosine hydroxylase-labeled neuron architecture in the mouse MPTP model of Parkinson's disease.Disease models & mechanisms · 2019Article
- Role of striatal ΔFosB in l-Dopa-induced dyskinesias of parkinsonian nonhuman primates.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Sensory neuropathy and nociception in rodent models of Parkinson's disease.Disease models & mechanisms · 2019Review
- Abnormal Mitochondria in a Non-human Primate Model of MPTP-induced Parkinson's Disease: Drp1 and CDK5/p25 Signaling.Experimental neurobiology · 2019Article
- The Rodent Models of Dyskinesia and Their Behavioral Assessment.Frontiers in neurology · 2019Review
- Pathophysiology of dyskinesia and behavioral disorders in non-human primates: the role of serotonergic fibers.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- MPTP Mouse Model of Preclinical and Clinical Parkinson's Disease as an Instrument for Translational Medicine.Molecular neurobiology · 2018Article
- Non-human primate models of PD to test novel therapies.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Loss and remodeling of striatal dendritic spines in Parkinson's disease: from homeostasis to maladaptive plasticity?Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
- Dysregulation of striatal projection neurons in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2018Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The non-human primate MPTP model of Parkinson's disease is an essential tool for translational studies. However, the currently used methodologies to produce parkinsonian monkeys do not follow unified criteria, and the applied models may often fall short of reproducing the characteristics of patients in clinical trials. Pooling of data from the parkinsonian monkeys produced in our Centers provided the opportunity to evaluate thoroughly the behavioral outcomes that may be considered for appropriate modeling in preclinical studies. We reviewed records from 108 macaques including rhesus and cynomolgus species used to model moderate to advanced parkinsonism with systemic MPTP treatment. The attained motor disability and the development of levodopa-induced dyskinesias, as primary outcomes, and the occurrence of clinical complications and instability of symptoms were all analyzed for correlations with the parameters of MPTP administration and for estimation of sample sizes. Results showed that frequently the MPTP-treated macaque can recapitulate the phenotype of patients entering clinical trials, but to produce this model consistently it is important to adapt the MPTP exposure tightly according to individual animal responses. For studies of reduced animal numbers it is also important to produce stable models, and stability of parkinsonism in macaques critically depends on reaching "marked" motor disability. The analyzed data also led to put forward recommendations for successfully producing the primate MPTP model of Parkinson's disease for translational studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.