ArticleBMC gastroenterology2013
Association between obesity and Barrett's esophagus in a Japanese population: a hospital-based, cross-sectional study.
Article in BMC gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Prevalence of Barrett's Esophagus and Esophageal Adenocarcinoma With and Without Gastroesophageal Reflux: A Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2024Pooled it
- Prevalence of Barrett's Esophagus in Asian Countries: A Systematic Review and Meta-analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2015Pooled it
- Endoscopic Evaluation of the Gastroesophageal Junction and Diagnosis of Barrett's Esophagus.Digestion · 2026Review
- Sponge cytology combined with endoscopy in patients with long-segment Barrett's esophagus: A retrospective case series and literature review.The Journal of international medical research · 2025Review
- Increased Prevalence of Barrett's Esophagus in Taiwan: A Prospective Multicenter Study.Journal of gastroenterology and hepatology · 2025Article
- Disease trends afterWorld journal of gastroenterology · 2023Article
- Observational
- Time trends in the incidence of esophageal adenocarcinoma, gastric adenocarcinoma, and superficial esophagogastric junction adenocarcinoma.Journal of gastroenterology · 2019Article
- Barrett's esophagus is negatively associated with eosinophilic esophagitis in Japanese subjects.Esophagus : official journal of the Japan Esophageal Society · 2019Observational
- Risk factors for Barrett's esophagus in young adults who underwent upper gastrointestinal endoscopy in a health examination center.Therapeutic advances in gastroenterology · 2019Article
- Impact of Obesity on a Chinese Population with Erosive Esophagitis and Barrett's Esophagus.Gut and liver · 2017Article
- Central Obesity and H. pylori Infection Influence Risk of Barrett's Esophagus in an Asian Population.PloS one · 2016Article
- Association of Visceral Fat Area, Smoking, and Alcohol Consumption with Reflux Esophagitis and Barrett's Esophagus in Japan.PloS one · 2015Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between obesity and Barrett's esophagus (BE) in the Japanese population remains unclear. The prevalence of BE and its associated risk factors was examined.
methodsA cross-sectional study of 1581 consecutive individuals who underwent upper gastrointestinal endoscopy was conducted. The prevalence of endoscopically suspected BE (ESBE) was evaluated. Obesity was evaluated by body mass index (BMI, ≥ 25 kg/m2) and waist circumference (WC) (males, ≥ 85 cm; females, ≥ 90 cm). Because endoscopic diagnosis of ultra-short ESBE (<1 cm in extent) is difficult and highly unreliable, this type of ESBE was excluded from the study.
resultsIn proton pump inhibitor (PPI) non-users, the prevalence of ESBE ≥ 1 cm was 5.6%. In univariate analysis, male sex and reflux esophagitis (RE) were significantly associated with BE, but BMI, WC, and reflux symptoms were not. In multivariate logistic regression analysis, only RE (odds ratio [OR] = 3.48, 95% confidence interval [CI] 1.89-6.41, p < 0.0001) was an independent risk factor for BE; obesity and the other factors were not. In contrast, RE (OR 5.67, p = 0.0004) and large WC (OR 5.09, p = 0.0005) were significant risk factors for ESBE ≥ 1 cm in PPI users. Only male sex, but not obesity or the other risk factors, was associated with an increased risk of RE in patients not taking PPIs.
conclusionsRE, but not obesity, may have an independent association with the risk of ESBE in the Japanese population. Furthermore, obesity measures were not independent risks for RE. Interestingly, PPI-refractory RE and large WC were risk factors for ESBE ≥1 cm in patients taking PPIs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.