ArticleBioMed research international2013
Microtubule-associated proteins in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with granular cell layer dispersion.
Article in BioMed research international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Histopathological Evidence of Neurodegenerative Pathology in Epilepsy: A Systematic Review.Annals of clinical and translational neurology · 2026Pooled it
- Altered Short Non-Coding RNA Landscape in the Hippocampus of a Mouse Model of CDKL5 Deficiency Disorder.Biomolecules · 2025Article
- Tauopathy and Epilepsy Comorbidities and Underlying Mechanisms.Frontiers in aging neuroscience · 2022Review
- Verbal memory dysfunction is associated with alterations in brain transcriptome in dominant temporal lobe epilepsy.Epilepsia · 2020Article
- Targeting neurodegeneration to prevent post-traumatic epilepsy.Neurobiology of disease · 2019Review
- Central nervous system lymphatic unit, immunity, and epilepsy: Is there a link?Epilepsia open · 2019Review
- Characterising subtypes of hippocampal sclerosis and reorganization: correlation with pre and postoperative memory deficit.Brain pathology (Zurich, Switzerland) · 2018Article
- Hyperphosphorylated tau in patients with refractory epilepsy correlates with cognitive decline: a study of temporal lobe resections.Brain : a journal of neurology · 2016Article
- Scope and limitations of yeast as a model organism for studying human tissue-specific pathways.BMC systems biology · 2015Article
- Mesial temporal lobe epilepsy with psychiatric comorbidities: a place for differential neuroinflammatory interplay.Journal of neuroinflammation · 2015Article
- Neurotrophin receptors expression in mesial temporal lobe epilepsy with and without psychiatric comorbidities and their relation with seizure type and surgical outcome.Acta neuropathologica communications · 2014Article
- Animal models of epilepsy: use and limitations.Neuropsychiatric disease and treatment · 2014Review
- Do Patients With Temporal Lobe Epilepsy and Cognitive Decline Have Alzheimer's Disease or Chronic Traumatic Encephalopathy (CTE)?Epilepsy currentsArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDespite strong association between epilepsy and psychiatric comorbidities, biological substrates are unknown. We have previously reported decreased mossy fiber sprouting in mesial temporal lobe epilepsy (MTLE) patients with psychosis and increased in those with major depression. Microtubule associated proteins (MAPs) are essentially involved in dendritic and synaptic sprouting.
methodsMTLE hippocampi of subjects without psychiatric history, MTLE + major depression, and MTLE + interictal psychosis derived from epilepsy surgery and control necropsies were investigated for neuronal density, granular layer dispersion, and MAP2 and tau immunohistochemistry.
resultsAltered MAP2 and tau expression in MTLE and decreased tau expression in MTLE with psychosis were found. Granular layer dispersion correlated inversely with verbal memory scores, and with MAP2 and tau expression in the entorhinal cortex. Patients taking fluoxetine showed increased neuronal density in the granular layer and those taking haloperidol decreased neuronal density in CA3 and subiculum.
conclusionsOur results indicate relations between MAPs, granular layer dispersion, and memory that have not been previously investigated. Differential MAPs expression in human MTLE hippocampi with and without psychiatric comorbidities suggests that psychopathological states in MTLE rely on differential morphological and possibly neurochemical backgrounds. This clinical study was approved by our institution's Research Ethics Board (HC-FMRP no. 1270/2008) and is registered under the Brazilian National System of Information on Ethics in Human Research (SISNEP) no. 0423.0.004.000-07.
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