ReviewJAK-STAT2013
Regulation of proliferation, cell competition, and cellular growth by the Drosophila JAK-STAT pathway.
Review in JAK-STAT, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- A Comparative Transcriptomic Analysis of X-Ray Irradiation Responses Identifies Candidate Biomarker Genes inInsects · 2026Article
- RhoGEF2 overexpression induces cell competition dependent on Ptp10D, Crumbs and the Hippo signaling pathway.Journal of cell science · 2025Article
- Cell competition in primary and metastatic colorectal cancer.Oncogenesis · 2024Review
- A Drosophila chemical screen reveals synergistic effect of MEK and DGKα inhibition in Ras-driven cancer.Disease models & mechanisms · 2023Article
- Proteasome α6 Subunit Negatively Regulates the JAK/STAT Pathway and Blood Cell Activation inFrontiers in immunology · 2021Article
- Oncogenic function of TRIM2 in pancreatic cancer by activating ROS-related NRF2/ITGB7/FAK axis.Oncogene · 2020Observational
- Prognostic value of key genes of the JAK-STAT signaling pathway in patients with cutaneous melanoma.Oncology letters · 2020Article
- Review
- Axin proteolysis by Iduna is required for the regulation of stem cell proliferation and intestinal homeostasis inDevelopment (Cambridge, England) · 2019Article
- Drosophila Models of Cell Polarity and Cell Competition in Tumourigenesis.Advances in experimental medicine and biology · 2019Review
- Drosophila Jak/STAT Signaling: Regulation and Relevance in Human Cancer and Metastasis.International journal of molecular sciences · 2018Review
- Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status.Nature communications · 2017Article
- TAZ Activator Is Involved in IL-10-Mediated Muscle Responses in an Animal Model of Traumatic Brain Injury.Inflammation · 2017Article
- Enhancer of polycomb coordinates multiple signaling pathways to promote both cyst and germline stem cell differentiation in the Drosophila adult testis.PLoS genetics · 2017Article
- Differential regulation of Janus kinase 3 (JAK3) in bovine preovulatory follicles and identification of JAK3 interacting proteins in granulosa cells.Journal of ovarian research · 2016Article
- Drosophila Wnt and STAT Define Apoptosis-Resistant Epithelial Cells for Tissue Regeneration after Irradiation.PLoS biology · 2016Article
- Troponin-I enhances and is required for oncogenic overgrowth.Oncotarget · 2016Article
- Interface Contractility between Differently Fated Cells Drives Cell Elimination and Cyst Formation.Current biology : CB · 2016Article
- Transcriptome Analysis and Gene Identification in the Pulmonary Artery of Broilers with Ascites Syndrome.PloS one · 2016Article
- A Flippase-Mediated GAL80/GAL4 Intersectional Resource for Dissecting Appendage Development in Drosophila.G3 (Bethesda, Md.) · 2015Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The JAK-STAT pathway is a key regulator of tissue size in Drosophila melanogaster. Here we provide an overview of its roles in processes that regulate the size of Drosophila imaginal discs, epithelia of diploid cells that proliferate and acquire specific fates in the larvae and that become functional in the adult. Drosophila has a single JAK and a single STAT gene, which has facilitated genetic dissection of this pathway. Moreover, the sophisticated genetic tools available in flies for clonal growth assays have made Drosophila an ideal organism in which to dissect the multiple roles of the JAK-STAT pathway in growth control. Studies in flies have revealed JAK-STAT pathway activity as a central node for diverse signals that control proliferation and mass accumulation. In addition, recent work has establish a new role for the pathway in cell competition, a process thought to be akin to the early stages of transformation in which more robust cells kill and take the place of less robust ones.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.