ArticlePLoS neglected tropical diseases2013
Sequence analysis and serological responses against Borrelia turicatae BipA, a putative species-specific antigen.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
30 citing papers in PubMed, 40 citations in OpenAlex.
- Serological evidence of Borrelia turicatae in Raccoons (Procyon lotor) from an endemic focus of tick-borne relapsing fever in Mexico.PLoS neglected tropical diseases · 2026Article
- Serological Analysis Indicating the Exposure of Two Volunteers to Relapsing Fever Borrelia sp. in Nayarit, Mexico.The American journal of tropical medicine and hygiene · 2025Article
- Late-stage borreliosis and substance abuse.Heliyon · 2024Article
- Direct Detection of Borrelia Species in Tissues.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Comparative genomics analysis of three conserved plasmid families in the Western Hemisphere soft tick-borne relapsing fever borreliae provides insight into variation in genome structure and antigenic variation systems.Microbiology spectrum · 2023Article
- A serological assay to detect and differentiate rodent exposure to soft tick and hard tick relapsing fever infections in the United States.Ticks and tick-borne diseases · 2023Article
- Comparative genomics analysis of three conserved plasmid families in the Western Hemisphere soft tick-borne relapsing fever borreliae provides insight into variation in genome structure and antigenic variation systems.bioRxiv : the preprint server for biology · 2023Article
- Characterization of Immunological Responses toMicrobiology spectrum · 2022Article
- Diversity and distribution of the tick-borne relapsing fever spirochete Borrelia turicatae.PLoS neglected tropical diseases · 2021Article
- Relapsing Fever Infection Manifesting as Aseptic Meningitis, Texas, USA.Emerging infectious diseases · 2021Article
- Isolation and genetic characterization of a relapsing fever spirochete isolated from Ornithodoros puertoricensis collected in central Panama.PLoS neglected tropical diseases · 2021Article
- Pathogenesis of Relapsing Fever.Current issues in molecular biology · 2021Review
- Characterization of a Borrelia miyamotoi membrane antigen (BmaA) for serodiagnosis of Borrelia miyamotoi disease.Ticks and tick-borne diseases · 2020Article
- Humoral immune response of pigs, Sus scrofa domesticus, upon repeated exposure to blood-feeding by Ornithodoros turicata Duges (Ixodida: Argasidae).Parasites & vectors · 2020Article
- Line Immunoblot Assay for Tick-Borne Relapsing Fever and Findings in Patient Sera from Australia, Ukraine and the USA.Healthcare (Basel, Switzerland) · 2019Article
- Antibodies to Borrelia turicatae in Experimentally Infected Dogs Cross-React with Borrelia burgdorferi Serologic Assays.Journal of clinical microbiology · 2019Article
- TickPath Layerplex: adaptation of a real-time PCR methodology for the simultaneous detection and molecular surveillance of tick-borne pathogens.Scientific reports · 2019Article
- Immunological Responses to the Relapsing Fever SpirocheteInfection and immunity · 2019Article
- Case report: A retrospective serological analysis indicating human exposure to tick-borne relapsing fever spirochetes in Sonora, Mexico.PLoS neglected tropical diseases · 2019Article
- Vector Competence of Geographical Populations of Ornithodoros turicata for the Tick-Borne Relapsing Fever Spirochete Borrelia turicatae.Applied and environmental microbiology · 2018Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRelapsing fever spirochetes are global yet neglected pathogens causing recurrent febrile episodes, chills, nausea, vomiting, and pregnancy complications. Given these nonspecific clinical manifestations, improving diagnostic assays for relapsing fever spirochetes will allow for identification of endemic foci and expedite proper treatment. Previously, an antigen designated the Borrelia immunogenic protein A (BipA) was identified in the North American species Borrelia hermsii. Thus far, BipA appears unique to relapsing fever spirochetes. The antigen remains unidentified outside of these pathogens, while interspecies amino acid identity for BipA in relapsing fever spirochetes is only 24-36%. The current study investigated the immunogenicity of BipA in Borrelia turicatae, a species distributed in the southern United States and Latin America. METHODOLOGY/PRINCIPAL
findingsbipA was amplified from six isolates of Borrelia turicatae, and sequence analysis demonstrated that the gene is conserved among isolates. A tick transmission system was developed for B. turicatae in mice and a canine, two likely vertebrate hosts, which enabled the evaluation of serological responses against recombinant BipA (rBipA). These studies indicated that BipA is antigenic in both animal systems after infection by tick bite, yet serum antibodies failed to bind to B. hermsii rBipA at a detectable level. Moreover, mice continued to generate an antibody response against BipA one year after the initial infection, further demonstrating the protein's potential toward identifying endemic foci for B. turicatae. CONCLUSIONS/SIGNIFICANCE: These initial studies support the hypothesis that BipA is a spirochete antigen unique to a relapsing fever Borrelia species, and could be used to improve efforts for identifying B. turicatae endemic regions.
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