ArticlePLoS neglected tropical diseases2013
Hospital-based surveillance for viral hemorrhagic fevers and hepatitides in Ghana.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 5 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Contemporary epidemiological data of Rift Valley fever virus in humans, mosquitoes and other animal species in Africa: A systematic review and meta-analysis.Veterinary medicine and science · 2023Pooled it
- Paving the way for human vaccination against Rift Valley fever virus: A systematic literature review of RVFV epidemiology from 1999 to 2021.PLoS neglected tropical diseases · 2022Pooled it
- Systematic review and meta-analysis of the epidemiology of Lassa virus in humans, rodents and other mammals in sub-Saharan Africa.PLoS neglected tropical diseases · 2020Pooled it
- A systematic review of the epidemiology of hepatitis A in Africa.BMC infectious diseases · 2019Pooled it
- Hepatitis E infection among Ghanaians: a systematic review.Infectious diseases of poverty · 2017Pooled it
- Detection of hepatitis viruses in suspected cases of Viral Haemorrhagic Fevers in Nigeria.PloS one · 2024Article
- Molecular Characterization of Circulating Yellow Fever Viruses from Outbreak in Ghana, 2021-2022.Emerging infectious diseases · 2023Article
- Epidemiology of Lassa Fever.Current topics in microbiology and immunology · 2023Article
- Assessing complexity and dynamics in epidemics: geographical barriers and facilitators of foot-and-mouth disease dissemination.Frontiers in veterinary science · 2023Article
- Hepatitis C virus (HCV) infection among patients with sickle cell disease at the Korle-Bu teaching hospital.Virology journal · 2022Article
- Sero-molecular epidemiology of hepatitis E virus in pigs and human contacts in Ghana.One health outlook · 2021Article
- "Kankasha" in Kassala: A prospective observational cohort study of the clinical characteristics, epidemiology, genetic origin, and chronic impact of the 2018 epidemic of Chikungunya virus infection in Kassala, Sudan.PLoS neglected tropical diseases · 2021Observational
- Circulation of hepatitis delta virus and occult hepatitis B virus infection amongst HIV/HBV co-infected patients in Korle-Bu, Ghana.PloS one · 2021Article
- Article
- Filovirus Disease Outbreaks: A Chronological Overview.Virology : research and treatment · 2019Review
- Development and evaluation of antibody-capture immunoassays for detection of Lassa virus nucleoprotein-specific immunoglobulin M and G.PLoS neglected tropical diseases · 2018Article
- Determination of specific antibody responses to the six species of ebola and Marburg viruses by multiplexed protein microarrays.Clinical and vaccine immunology : CVI · 2014Article
- Aetiology of PCR negative suspected Crimean-Congo hemorrhagic fever cases in an endemic area.Pathogens and global healthArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundViral hemorrhagic fevers (VHF) are acute diseases associated with bleeding, organ failure, and shock. VHF may hardly be distinguished clinically from other diseases in the African hospital, including viral hepatitis. This study was conducted to determine if VHF and viral hepatitis contribute to hospital morbidity in the Central and Northern parts of Ghana. METHODOLOGY/PRINCIPAL
findingsFrom 2009 to 2011, blood samples of 258 patients with VHF symptoms were collected at 18 hospitals in Ashanti, Brong-Ahafo, Northern, Upper West, and Upper East regions. Patients were tested by PCR for Lassa, Rift Valley, Crimean-Congo, Ebola/Marburg, and yellow fever viruses; hepatitis A (HAV), B (HBV), C (HCV), and E (HEV) viruses; and by ELISA for serological hepatitis markers. None of the patients tested positive for VHF. However, 21 (8.1%) showed anti-HBc IgM plus HBV DNA and/or HBsAg; 37 (14%) showed HBsAg and HBV DNA without anti-HBc IgM; 26 (10%) showed anti-HAV IgM and/or HAV RNA; and 20 (7.8%) were HCV RNA-positive. None was positive for HEV RNA or anti-HEV IgM plus IgG. Viral genotypes were determined as HAV-IB, HBV-A and E, and HCV-1, 2, and 4. CONCLUSIONS/SIGNIFICANCE: VHFs do not cause significant hospital morbidity in the study area. However, the incidence of acute hepatitis A and B, and hepatitis B and C with active virus replication is high. These infections may mimic VHF and need to be considered if VHF is suspected. The data may help decision makers to allocate resources and focus surveillance systems on the diseases of relevance in Ghana.
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