ArticlePLoS neglected tropical diseases2013
Mosquito-parasite interactions can shape filariasis transmission dynamics and impact elimination programs.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A Trial of a Triple-Drug Treatment for Lymphatic Filariasis.The New England journal of medicine · 2018Trial
- Mosquito vectors of lymphatic and zoonotic filariasis in Malaysia: a systematic review and proportionate meta-analysis of infection rates.Tropical medicine and health · 2026Review
- Brugia malayi and other filarial parasite species in animals in areas endemic for lymphatic filariasis in Belitung District, Indonesia.PLoS neglected tropical diseases · 2025Article
- Current Status of the Diagnosis ofPathogens (Basel, Switzerland) · 2024Review
- Case 17-2023: A 58-Year-Old Woman with Fatigue, Abdominal Bloating, and Eosinophilia.The New England journal of medicine · 2023Article
- Mathematical study of the dynamics of lymphatic filariasis infection via fractional-calculus.European physical journal plus · 2023Article
- Mosquito-Borne Diseases Emergence/Resurgence and How to Effectively Control It Biologically.Pathogens (Basel, Switzerland) · 2020Review
- Human Migration and the Spread of the Nematode Parasite Wuchereria bancrofti.Molecular biology and evolution · 2019Article
- Immune responses of Aedes togoi, Anopheles paraliae and Anopheles lesteri against nocturnally subperiodic Brugia malayi microfilariae during migration from the midgut to the site of development.Parasites & vectors · 2018Article
- The History of Bancroftian Lymphatic Filariasis in Australasia and Oceania: Is There a Threat of Re-Occurrence in Mainland Australia?Tropical medicine and infectious disease · 2018Review
- Insulin receptor knockdown blocks filarial parasite development and alters egg production in the southern house mosquito, Culex quinquefasciatus.PLoS neglected tropical diseases · 2018Article
- Mathematical analysis of a lymphatic filariasis model with quarantine and treatment.BMC public health · 2017Article
- Modeling the Parasitic Filariasis Spread by Mosquito in Periodic Environment.Computational and mathematical methods in medicine · 2017Article
- Filarial infection influences mosquito behaviour and fecundity.Scientific reports · 2016Article
- Population genomics of the filarial nematode parasite Wuchereria bancrofti from mosquitoes.Molecular ecology · 2016Article
- Presence of Wuchereria bancrofti microfilaremia despite 7 years of annual ivermectin monotherapy mass drug administration for onchocerciasis control: a study in north-west Ethiopia.Pathogens and global health · 2015Article
- Fit for purpose: do we have the right tools to sustain NTD elimination?BMC proceedings · 2015Article
- How effective is integrated vector management against malaria and lymphatic filariasis where the diseases are transmitted by the same vector?PLoS neglected tropical diseases · 2014Article
- Molecular epidemiology, phylogeny and evolution of the filarial nematode Wuchereria bancrofti.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2014Review
- Dual RNA-seq of parasite and host reveals gene expression dynamics during filarial worm-mosquito interactions.PLoS neglected tropical diseases · 2014Article
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Abstract
The relationship between mosquito vectors and lymphatic filariasis (LF) parasites can result in a range of transmission outcomes. Anophelines are generally characterized as poor vectors due to an inability to support development at low densities. However, it is important to understand the potential for transmission in natural vectors to maximize the success of elimination efforts. Primary vectors in Papua New Guinea (n = 1209) were dissected following exposure to microfilaremic blood (range 8-233 mf/20 µl). We examined density dependent and species-specific parasite prevalence, intensity and yield, barriers to parasite development as well as impacts on mosquito survival. We observed strikingly different parasite prevalence and yield among closely related species. Prevalence of infective stage larvae (L3s) ranged from 4.2% to 23.7% in An. punctulatus, 24.5% to 68.6% in An. farauti s.s. and 61.9% to 100% in An. hinesorum at low and high density exposures, respectively. Injection experiments revealed the greatest barrier to parasite development involved passage from the midgut into the hemocoel. The ratio of L3 to ingested mf at low densities was higher in An. hinesorum (yield = 1.0) and An. farauti s.s. (yield = 0.5) than has been reported in other anopheline vectors. There was a negative relationship between mosquito survival and bloodmeal mf density. In An. farauti s.s., increased parasite yield and survival at low densities suggest greater competence at low microfilaremias. In Papua New Guinea the likelihood of transmission will be strongly influenced by vector composition and changes in the mf reservoir as a result of elimination efforts. Global elimination efforts will be strengthened by the knowledge of transmission potential in the context of current control measures.
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