ArticlePloS one2013
Pseudomonas aeruginosa adaptation to lungs of cystic fibrosis patients leads to lowered resistance to phage and protist enemies.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- The Role of Quorum Sensing in Phage Lifecycle Decision: A Switch Between Lytic and Lysogenic Pathways.Viruses · 2025Review
- Article
- Trade-offs of lipid remodeling in a marine predator-prey interaction in response to phosphorus limitation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Functional diversity increases the efficacy of phage combinations.Microbiology (Reading, England) · 2021Article
- Filamentous bacteriophages are associated with chronicScience translational medicine · 2019Article
- Pathogen dynamics under both bottom-up host resistance and top-down hyperparasite attack.The Journal of applied ecology · 2018Article
- Life in the cystic fibrosis upper respiratory tract influences competitive ability of the opportunistic pathogenRoyal Society open science · 2018Article
- Article
- Use of a Primary Epithelial Cell Screening Tool to Investigate Phage Therapy in Cystic Fibrosis.Frontiers in pharmacology · 2018Article
- Generalized Growth of Estuarine, Household and Clinical Isolates ofFrontiers in microbiology · 2018Article
- Burkholderia cenocepacia virulence microevolution in the CF lung: Variations on a theme.Virulence · 2017Article
- Variation of Burkholderia cenocepacia virulence potential during cystic fibrosis chronic lung infection.Virulence · 2017Article
- Bacterial competition and quorum-sensing signalling shape the eco-evolutionary outcomes of modelEvolutionary applications · 2017Article
- Identification of Essential Genes in the Salmonella Phage SPN3US Reveals Novel Insights into Giant Phage Head Structure and Assembly.Journal of virology · 2016Article
- The role of hyperparasitism in microbial pathogen ecology and evolution.The ISME journal · 2016Review
- Modular Approach to Select Bacteriophages TargetingFrontiers in microbiology · 2016Review
- Within-host evolution decreases virulence in an opportunistic bacterial pathogen.BMC evolutionary biology · 2015Article
- Bacteriophage-based therapy in cystic fibrosis-associated Pseudomonas aeruginosa infections: rationale and current status.Drug design, development and therapy · 2015Review
- Phages can constrain protist predation-driven attenuation of Pseudomonas aeruginosa virulence in multienemy communities.The ISME journal · 2014Article
- Pseudomonas aeruginosa isolates from dental unit waterlines can be divided in two distinct groups, including one displaying phenotypes similar to isolates from cystic fibrosis patients.Frontiers in microbiology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Pathogenic life styles can lead to highly specialized interactions with host species, potentially resulting in fitness trade-offs in other ecological contexts. Here we studied how adaptation of the environmentally transmitted bacterial pathogen, Pseudomonas aeruginosa, to cystic fibrosis (CF) patients affects its survival in the presence of natural phage (14/1, ΦKZ, PNM and PT7) and protist (Tetrahymena thermophila and Acanthamoebae polyphaga) enemies. We found that most of the bacteria isolated from relatively recently intermittently colonised patients (1-25 months), were innately phage-resistant and highly toxic for protists. In contrast, bacteria isolated from long time chronically infected patients (2-23 years), were less efficient in both resisting phages and killing protists. Moreover, chronic isolates showed reduced killing of wax moth larvae (Galleria mellonella) probably due to weaker in vitro growth and protease expression. These results suggest that P. aeruginosa long-term adaptation to CF-lungs could trade off with its survival in aquatic environmental reservoirs in the presence of microbial enemies, while lowered virulence could reduce pathogen opportunities to infect insect vectors; factors that are both likely to result in poorer environmental transmission. From an applied perspective, phage therapy could be useful against chronic P. aeruginosa lung infections that are often characterized by multidrug resistance: chronic isolates were least resistant to phages and their poor growth will likely slow down the emergence of beneficial resistance mutations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.