ArticlePloS one2013
Noise-induced tinnitus using individualized gap detection analysis and its relationship with hyperacusis, anxiety, and spatial cognition.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 45 citations in OpenAlex.
- Conductive hearing loss does not affect spatial learning and memory in middle-aged guinea pigs.Scientific reports · 2024Article
- Alterations of the cerebral microstructure in patients with noise-induced hearing loss: A diffusion tensor imaging study.Brain and behavior · 2024Article
- Pharmacological Evaluation of Drugs in Animal Models of Tinnitus.Current topics in behavioral neurosciences · 2021Review
- Resistance to noise-induced gap detection impairment in FVB mice is correlated with reduced neuroinflammatory response and parvalbumin-positive neuron loss.Scientific reports · 2020Article
- Auditory Brainstem Responses (ABR) of Rats during Experimentally Induced Tinnitus: Literature Review.Brain sciences · 2020Review
- Neurocognition of Aged Patients With Chronic Tinnitus: Focus on Mild Cognitive Impairment.Clinical and experimental otorhinolaryngology · 2020Article
- Tinnitus Correlates with Downregulation of Cortical Glutamate Decarboxylase 65 Expression But Not Auditory Cortical Map Reorganization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Inhibition of Experimental Tinnitus With High Frequency Stimulation of the Rat Medial Geniculate Body.Neuromodulation : journal of the International Neuromodulation Society · 2019Article
- Behavioral Animal Model of the Emotional Response to Tinnitus and Hearing Loss.Journal of the Association for Research in Otolaryngology : JARO · 2018Article
- Blast-Induced Tinnitus and Elevated Central Auditory and Limbic Activity in Rats: A Manganese-Enhanced MRI and Behavioral Study.Scientific reports · 2017Article
- Improving the Reliability of Tinnitus Screening in Laboratory Animals.Journal of the Association for Research in Otolaryngology : JARO · 2017Article
- Article
- High pressure air jet in the endoscopic preparation room: risk of noise exposure on occupational health.BioMed research international · 2015Article
- Tinnitus-related changes in the inferior colliculus.Frontiers in neurology · 2015Review
- Gap-Prepulse Inhibition of the Acoustic Startle Reflex (GPIAS) for Tinnitus Assessment: Current Status and Future Directions.Frontiers in neurology · 2015Review
- Cannabinoid CB1 Receptor Agonists Do Not Decrease, but may Increase Acoustic Trauma-Induced Tinnitus in Rats.Frontiers in neurology · 2015Article
- Modulating central gain in tinnitus: changes in nitric oxide synthase in the ventral cochlear nucleus.Frontiers in neurology · 2015Article
- Salicylate-induced hearing loss and gap detection deficits in rats.Frontiers in neurology · 2015Article
- Prolonged noise exposure-induced auditory threshold shifts in rats.Hearing research · 2014Article
- Neural changes accompanying tinnitus following unilateral acoustic trauma in the guinea pig.The European journal of neuroscience · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tinnitus has a complex etiology that involves auditory and non-auditory factors and may be accompanied by hyperacusis, anxiety and cognitive changes. Thus far, investigations of the interrelationship between tinnitus and auditory and non-auditory impairment have yielded conflicting results. To further address this issue, we noise exposed rats and assessed them for tinnitus using a gap detection behavioral paradigm combined with statistically-driven analysis to diagnose tinnitus in individual rats. We also tested rats for hearing detection, responsivity, and loss using prepulse inhibition and auditory brainstem response, and for spatial cognition and anxiety using Morris water maze and elevated plus maze. We found that our tinnitus diagnosis method reliably separated noise-exposed rats into tinnitus((+)) and tinnitus((-)) groups and detected no evidence of tinnitus in tinnitus((-)) and control rats. In addition, the tinnitus((+)) group demonstrated enhanced startle amplitude, indicating hyperacusis-like behavior. Despite these results, neither tinnitus, hyperacusis nor hearing loss yielded any significant effects on spatial learning and memory or anxiety, though a majority of rats with the highest anxiety levels had tinnitus. These findings showed that we were able to develop a clinically relevant tinnitus((+)) group and that our diagnosis method is sound. At the same time, like clinical studies, we found that tinnitus does not always result in cognitive-emotional dysfunction, although tinnitus may predispose subjects to certain impairment like anxiety. Other behavioral assessments may be needed to further define the relationship between tinnitus and anxiety, cognitive deficits, and other impairments.
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