ArticlePloS one2013
The prevalence of nine genetic disorders in a dog population from Belgium, the Netherlands and Germany.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Breed Distribution of the Superoxide Dismutase 1 Gene Polymorphism Associated With Degenerative Myelopathy in a Canine Population From Different Geographical Regions of Türkiye.Veterinary medicine and science · 2026Article
- Molecular Surveillance of Canine Degenerative Myelopathy in Breeding Kennels from Romania.Animals : an open access journal from MDPI · 2023Article
- Allele and genotype frequencies of theVeterinary world · 2021Article
- A Leaky Noisy-OR Bayesian Network Applied to Genetic Counseling in Dogs.Animals : an open access journal from MDPI · 2020Article
- Article
- Frequency of five disease-causing genetic mutations in a large mixed-breed dog population (2011-2012).PloS one · 2017Article
- Long-term outcome of myotonia associated with hyperadrenocorticism in 2 dogs.The Canadian veterinary journal = La revue veterinaire canadienne · 2015Article
- Improved canine exome designs, featuring ncRNAs and increased coverage of protein coding genes.Scientific reports · 2015Article
- Development and performance of a targeted whole exome sequencing enrichment kit for the dog (Canis Familiaris Build 3.1).Scientific reports · 2014Article
- Identification and validation of quantitative trait loci (QTL) for canine hip dysplasia (CHD) in German Shepherd Dogs.PloS one · 2014Article
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to screen a dog population from Belgium, the Netherlands and Germany for the presence of mutant alleles associated with hip dysplasia (HD), degenerative myelopathy (DM), exercise-induced collapse (EIC), neuronal ceroid lipofuscinosis 4A (NCL), centronuclear myopathy (HMLR), mucopolysaccharidosis VII (MPS VII), myotonia congenita (MG), gangliosidosis (GM1) and muscular dystrophy (Duchenne type) (GRMD). Blood samples (K3EDTA) were collected for genotyping with Kompetitive Allele Specific PCR (n = 476). Allele and genotype frequencies were calculated in those breeds with at least 12 samples (n = 8). Hardy-Weinberg equilibrium was tested. Genetic variation was identified for 4 out of 9 disorders: mutant alleles were found in 49, 15, 3 and 2 breeds for HD, DM, EIC and NCL respectively. Additionally, mutant alleles were identified in crossbreeds for both HD and EIC. For HD, DM, EIC and NCL mutant alleles were newly discovered in 43, 13, 2 and 1 breed(s), respectively. In 9, 2 and 1 breed(s) for DM, EIC and NCL respectively, the mutant allele was detected, but the respective disorder has not been reported in those breeds. For 5 disorders (HMLR, MPS VII, MG, GM1, GRMD), the mutant allele could not be identified in our population. For the other 4 disorders (HD, DM, EIC, NCL), prevalence of associated mutant alleles seems strongly breed dependent. Surprisingly, mutant alleles were found in many breeds where the disorder has not been reported to date.
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