ArticlePloS one2013
Gene expression profile of peripheral blood monocytes: a step towards the molecular diagnosis of celiac disease?
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 27 citations in OpenAlex.
- Exposure to PFOS and PFOA through drinking water is associated with greater cigarette smoke-induced COPD-like lung injury and enhanced NF-κB-related inflammatory signaling in mice.Current research in toxicology · 2026Article
- Gluten consumption and inflammation affect the development of celiac disease in at-risk children.Scientific reports · 2022Article
- Inflammation Is Present, Persistent and More Sensitive to Proinflammatory Triggers in Celiac Disease Enterocytes.International journal of molecular sciences · 2022Article
- Celiac disease in pediatric patients according to HLA genetic risk classes: a retrospective observational study.Italian journal of pediatrics · 2021Observational
- Perturbations in Endocytotic and Apoptotic Pathways Are Associated With Chemotherapy-Induced Nausea.Biological research for nursing · 2021Article
- Evaluation of expression of common genes in the intestine and peripheral blood mononuclear cells (PBMC) associated with celiac disease.Gastroenterology and hepatology from bed to bench · 2020Article
- A Phospholipid Profile at 4 Months Predicts the Onset of Celiac Disease in at-Risk Infants.Scientific reports · 2019Article
- Combined Analysis of Methylation and Gene Expression Profiles in Separate Compartments of Small Bowel Mucosa Identified Celiac Disease Patients' Signatures.Scientific reports · 2019Article
- Non-Invasive Biomarkers for Celiac Disease.Journal of clinical medicine · 2019Review
- Comparison of cytokine and gene activities in tissue and blood samples of patients with celiac disease.Gastroenterology and hepatology from bed to bench · 2019Article
- The Transcriptomic Analysis of Circulating Immune Cells in a Celiac Family Unveils Further Insights Into Disease Pathogenesis.Frontiers in medicine · 2018Article
- Article
- Clinical and diagnostic aspects of gluten related disorders.World journal of clinical cases · 2015Review
- Potential blood-based markers of celiac disease.BMC gastroenterology · 2014Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimCeliac disease (CD) is a multifactorial autoimmune disease induced by ingestion of gluten in genetically predisposed individuals. Despite technological progress, the diagnosis of CD is still based on duodenal biopsy as it was 50 years ago. In this study we analysed the expression of CD-associated genes in small bowel biopsies of patients and controls in order to explore the multivariate pathway of the expression profile of CD patients. Then, using multivariant discriminant analysis, we evaluated whether the expression profiles of these genes in peripheral blood monocytes (PBMs) differed between patients and controls.
participantsThirty-seven patients with active and 11 with treated CD, 40 healthy controls and 9 disease controls (Crohn's disease patients) were enrolled.
resultsSeveral genes were differentially expressed in CD patients versus controls, but the analysis of each single gene did not provided a comprehensive picture. A multivariate discriminant analysis showed that the expression of 5 genes in intestinal mucosa accounted for 93% of the difference between CD patients and controls. We then applied the same approach to PBMs, on a training set of 20 samples. The discriminant equation obtained was validated on a testing cohort of 10 additional cases and controls, and we obtained a correct classification of all CD cases and of 91% of the control samples. We applied this equation to treated CD patients and to disease controls and obtained a discrimination of 100%.
conclusionsThe combined expression of 4 genes allows one to discriminate between CD patients and controls, and between CD patients on a gluten-free diet and disease controls. Our results contribute to the understanding of the complex interactions among CD-associated genes, and they may represent a starting point for the development of a molecular diagnosis of celiac disease.
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