ArticlePloS one2013
Conscious wireless electroretinogram and visual evoked potentials in rats.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Inter-session repeatability of electroretinography and visual evoked potentials of the Celeris system.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Targeting glial fibrillary acidic protein in glaucoma: a monoclonal antibody approach to modulate glial reactivity and neuroinflammation for neuroprotection.Journal of neuroinflammation · 2025Article
- Development of a wireless electroretinogram recording system.Scientific reports · 2025Article
- Comparisons of α2-Adrenergic Agents, Medetomidine and Xylazine, with Pentobarbital for Anesthesia: Important Pitfalls in Diabetic and Nondiabetic Rats.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2022Article
- Pupil dilation and constriction in the skate Leucoraja erinacea in a simulated natural light field.The Journal of experimental biology · 2022Article
- Non-invasive visual evoked potentials under sevofluraneHeliyon · 2021Article
- A new electrophysiological non-invasive method to assess retinocortical conduction time in the Dark Agouti rat through the simultaneous recording of electroretinogram and visual evoked potential.Documenta ophthalmologica. Advances in ophthalmology · 2020Article
- Electroencephalographic, physiologic and behavioural responses during cervical dislocation euthanasia in turkeys.BMC veterinary research · 2019Article
- Quantification of Changes in Visual Function During Disease Development in a Mouse Model of Pigmentary Glaucoma.Journal of glaucoma · 2018Article
- Simultaneous Recording of Electroretinography and Visual Evoked Potentials in Anesthetized Rats.Journal of visualized experiments : JoVE · 2016Article
- Implantation and Recording of Wireless Electroretinogram and Visual Evoked Potential in Conscious Rats.Journal of visualized experiments : JoVE · 2016Article
- Measurement of Electroretinograms and Visually Evoked Potentials in Awake Moving Mice.PloS one · 2016Article
- Retinal Electrophysiology Is a Viable Preclinical Biomarker for Drug Penetrance into the Central Nervous System.Journal of ophthalmology · 2016Article
- Using the Electroretinogram to Assess Function in the Rodent Retina and the Protective Effects of Remote Limb Ischemic Preconditioning.Journal of visualized experiments : JoVE · 2015Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The electroretinogram (ERG, retina) and visual evoked potential (VEP, brain) are widely used in vivo tools assaying the integrity of the visual pathway. Current recordings in preclinical models are conducted under anesthesia, which alters neural physiology and contaminates responses. We describe a conscious wireless ERG and VEP recording platform in rats. Using a novel surgical technique to chronically implant electrodes subconjunctivally on the eye and epidurally over the visual cortex, we are able to record stable and repeatable conscious ERG and VEP signals over at least 1 month. We show that the use of anaesthetics, necessary for conventional ERG and VEP measurements, alters electrophysiology recordings. Conscious visual electrophysiology improves the viability of longitudinal studies by eliminating complications associated with repeated anaesthesia. It will also enable uncontaminated assessment of drug effects, allowing the eye to be used as an effective biomarker of the central nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.