Evidence map›Paper›PMID 24069252›Full record

ArticlePloS one2013

Caspases and p38 MAPK regulate endothelial cell adhesiveness for mesenchymal stem cells.

Irina A Potapova, Ira S Cohen, Sergey V Doronin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Irina A PotapovaDepartment of Physiology and Biophysics, Institute of Molecular Cardiology, Stony Brook University, Stony Brook, New York, United States of America.
Ira S Cohen
Sergey V Doronin
Stony Brook University · US

Funding

Novel ion channel approaches to reentrant arrythymiasR01HL094410 · NHLBI · STATE UNIVERSITY NEW YORK STONY BROOK · PI COHEN, IRA S · 2009 to 2013
$3.8M
NHLBI NIH HHS HL094410NHLBI NIH HHS R01 HL094410PHS HHS GMR0188180
6 · The paper itself

Abstract

Mesenchymal stem cells natively circulating or delivered into the blood stream home to sites of injury. The mechanism of mesenchymal stem cell homing to sites of injury is poorly understood. We have shown that the development of apoptosis in endothelial cells stimulates endothelial cell adhesiveness for mesenchymal stem cells. Adhesion of mesenchymal stem cells to apoptotic endothelial cells depends on the activation of endothelial caspases and p38 MAPK. Activation of p38 MAPK in endothelial cells has a primary effect while the activation of caspases potentiates the mesenchymal stem cell adhesion. Overall, our study of the mesenchymal stem cell interaction with endothelial cells indicates that mesenchymal stem cells recognize and specifically adhere to distressed/apoptotic endothelial cells.

Indexed as

Caspase InhibitorsCaspasesCell AdhesionCells, CulturedEndothelial CellsEnzyme ActivationHumansHuman Umbilical Vein Endothelial CellsLipoxygenaseMembrane Potential, MitochondrialMesenchymal Stem CellsMitochondriap38 Mitogen-Activated Protein KinasesPhospholipases A2PhosphorylationCaspase InhibitorsCaspasesLipoxygenasep38 Mitogen-Activated Protein KinasesPhospholipases A2

Identifiers

PMID24069252
PMCPMC3771880
OpenAlexW2018667745

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.