ArticlePloS one2013
Regional HLA differences in Poland and their effect on stem cell donor registry planning.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Age-dependent HLA profiles of the Israeli population: impact on hematopoietic cell donor recruitment and availability.Immunogenetics · 2014Trial
- HLA Linked Regional Differences in Donor Selection: A 9-Year Study of the Swiss Registry.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Article
- Genetic diversity in Kashubs: the regional increase in the frequency of several disease-causing variants.Journal of applied genetics · 2022Review
- Article
- Mapping the Human Leukocyte Antigen Diversity among Croatian Regions: Implication in Transplantation.Journal of immunology research · 2021Article
- Immunogenetics in stem cell donor registry work: The DKMS example (Part 1).International journal of immunogenetics · 2020Review
- Article
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Authors and funding
10 authors.
Funding
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Abstract
Regional HLA frequency differences are of potential relevance for the optimization of stem cell donor recruitment. We analyzed a very large sample (n = 123,749) of registered Polish stem cell donors. Donor figures by 1-digit postal code regions ranged from n = 5,243 (region 9) to n = 19,661 (region 8). Simulations based on region-specific haplotype frequencies showed that donor recruitment in regions 0, 2, 3 and 4 (mainly located in the south-eastern part of Poland) resulted in an above-average increase of matching probabilities for Polish patients. Regions 1, 7, 8, 9 (mainly located in the northern part of Poland) showed an opposite behavior. However, HLA frequency differences between regions were generally small. A strong indication for regionally focused donor recruitment efforts can, therefore, not be derived from our analyses. Results of haplotype frequency estimations showed sample size effects even for sizes between n≈5,000 and n≈20,000. This observation deserves further attention as most published haplotype frequency estimations are based on much smaller samples.
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