ArticlePloS one2013
Identification and characterization of cancer mutations in Japanese lung adenocarcinoma without sequencing of normal tissue counterparts.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- AHCYL1 mediates the tumor-promoting effect of PREX2 in non-small cell lung carcinoma.Theranostics · 2025Article
- Understanding P-Rex regulation: structural breakthroughs and emerging perspectives.Biochemical Society transactions · 2024Review
- PAPPA2 mutation as a novel indicator stratifying beneficiaries of immune checkpoint inhibitors in skin cutaneous melanoma and non-small cell lung cancer.Cell proliferation · 2022Article
- Comprehensive genomic profile of Chinese lung cancer patients and mutation characteristics of individuals resistant to icotinib/gefitinib.Scientific reports · 2020Article
- Long-read sequencing for non-small-cell lung cancer genomes.Genome research · 2020Article
- CELF2 suppresses non-small cell lung carcinoma growth by inhibiting the PREX2-PTEN interaction.Carcinogenesis · 2020Article
- Pregnancy-Associated Plasma Protein-A2 Is Associated With Mortality in Patients With Lung Cancer.Frontiers in endocrinology · 2020Article
- Characterization of cancer omics and drug perturbations in panels of lung cancer cells.Scientific reports · 2019Article
- Detection of Molecular Alterations in Taiwanese Patients with Medullary Thyroid Cancer Using Whole-Exome Sequencing.Endocrine pathology · 2018Article
- Podoplanin-positive cancer-associated fibroblast recruitment within cancer stroma is associated with a higher number of single nucleotide variants in cancer cells in lung adenocarcinoma.Journal of cancer research and clinical oncology · 2018Article
- DBTSS/DBKERO for integrated analysis of transcriptional regulation.Nucleic acids research · 2018Article
- Treatment of lung adenocarcinoma by molecular-targeted therapy and immunotherapy.Surgery today · 2018Review
- Sequencing and phasing cancer mutations in lung cancers using a long-read portable sequencer.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Routine genetic testing of lung cancer specimens derived from surgery, bronchoscopy and fluid aspiration by next generation sequencing.International journal of oncology · 2017Article
- Whole genome sequencing analysis of lung adenocarcinoma in Xuanwei, China.Thoracic cancer · 2017Article
- Receptor tyrosine kinase amplification is predictive of distant metastasis in patients with oral squamous cell carcinoma.Cancer science · 2017Article
- Gene polymorphisms and oral cancer risk in tobacco habitués.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- TMC-SNPdb: an Indian germline variant database derived from whole exome sequences.Database : the journal of biological databases and curation · 2016Article
- Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance.Genome medicine · 2015Article
- Signaling through the Phosphatidylinositol 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Axis Is Responsible for Aerobic Glycolysis mediated by Glucose Transporter in Epidermal Growth Factor Receptor (EGFR)-mutated Lung Adenocarcinoma.The Journal of biological chemistry · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed whole-exome sequencing data from 97 Japanese lung adenocarcinoma patients and identified several putative cancer-related genes and pathways. Particularly, we observed that cancer-related mutation patterns were significantly different between different ethnic groups. As previously reported, mutations in the EGFR gene were characteristic to Japanese, while those in the KRAS gene were more frequent in Caucasians. Furthermore, during the course of this analysis, we found that cancer-specific somatic mutations can be detected without sequencing normal tissue counterparts. 64% of the germline variants could be excluded using a total of 217 external Japanese exome datasets. We also show that a similar approach may be used for other three ethnic groups, although the discriminative power depends on the ethnic group. We demonstrate that the ATM gene and the PAPPA2 gene could be identified as cancer prognosis related genes. By bypassing the sequencing of normal tissue counterparts, this approach provides a useful means of not only reducing the time and cost of sequencing but also analyzing archive samples, for which normal tissue counterparts are not available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.