ArticlePloS one2013
A genetic polymorphism in TOX3 is associated with survival of gastric cancer in a Chinese population.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Clinical research of intraperitoneal implantation of sustained-release 5-fluorouracil in advanced colorectal cancer.World journal of surgical oncology · 2015Trial
- Identification and Mechanism of the PD-1/PD-L1 Genomic SignatureFrontiers in genetics · 2021Article
- Molecular profiling of TOX-deficient neoplastic cells in cutaneous T cell lymphoma.Archives of dermatological research · 2020Article
- Association between the TOX3 rs3803662 C>T polymorphism and recurrent miscarriage in a southern Chinese population.Journal of clinical laboratory analysis · 2019Article
- TOX3 is a favorable prognostic indicator and potential immunomodulatory factor in lung adenocarcinoma.Oncology letters · 2019Article
- MAP3K1 rs889312 genotypes influence survival outcomes of Chinese gastric cancer patients who received adjuvant chemotherapy based on platinum and fluorouracil regimes.OncoTargets and therapy · 2019Article
- TOX3 protein expression is correlated with pathological characteristics in breast cancer.Oncology letters · 2016Article
- Genetic variability of DNA repair mechanisms influences treatment outcome of gastric cancer.Oncology letters · 2015Article
- TOX gene: a novel target for human cancer gene therapy.American journal of cancer research · 2015Review
- Clinical significance of POU5F1P1 rs10505477 polymorphism in Chinese gastric cancer patients receving cisplatin-based chemotherapy after surgical resection.International journal of molecular sciences · 2014Article
Corrections and comments
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Authors and funding
14 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeRecently, genetic polymorphism (rs3803662C>T) in TOX3 was reported to induce the risk of breast cancer. In this study, we hypothesized that rs3803662 could influence gastric cancer survival outcomes.
methodsWith multiplex SNaPshot method, we genotyped TOX3 rs3803662 in 880 gastric patients with surgical resection. The association between genotype and survival outcomes was performed by the Kaplan-Meier method, Cox regression analysis models and the log-rank test.
resultsThere was no association in the analyses of rs3803662 and survival of gastric cancer. However, the stratified analysis by histology showed that rs3803662 CT/TT genotype was associated with a significantly better survival for diffuse-type gastric cancer (log-rank p = 0.030, hazard ratio [HR] = 0.67, 95% confidence interval [CI] = 0.46-0.96), than the CC genotype. In addition, this favorable effect was especially obvious among gastric cancer patients with tumor size >5 cm, T3 and T4 depth of invasion, lymph node metastasis, no drinking, no distant metastasis, no chemotherapy and gastric cardia cancer.
conclusionsTOX3 rs3803662 might play an important role in the prognostic outcome and treatment of gastric cancer, especially perhaps further help in explaining the reduced risk of death associated with diffuse-type gastric cancer.
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