ArticleEvidence-based complementary and alternative medicine : eCAM2013
An Experimental Novel Study: Angelica sinensis Prevents Epidural Fibrosis in Laminectomy Rats via Downregulation of Hydroxyproline, IL-6, and TGF- β 1.
Article in Evidence-based complementary and alternative medicine : eCAM, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Pharmacotherapies to prevent epidural fibrosis after laminectomy: a systematic review of in vitro and in vivo animal models.The spine journal : official journal of the North American Spine Society · 2023Pooled it
- Experimental evaluation of femoral vein grafts and platelet-rich fibrin for reducing epidural fibrosis in a rat laminectomy model.Scientific reports · 2026Article
- Research Progress on the Immunomodulatory Effects by Dang Gui (Molecules (Basel, Switzerland) · 2026Review
- Review
- Tiaoshen Tongluo Attenuates Fibrosis by Modulating the TGF-Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Celecoxib-Loaded Electrospun Fibrous Antiadhesion Membranes Reduce COX-2/PGENeural plasticity · 2021Article
- Honokiol protects against epidural fibrosis by inhibiting fibroblast proliferation and extracellular matrix overproduction in rats post‑laminectomy.International journal of molecular medicine · 2020Article
- Effectiveness of Gelatin-Thrombin Matrix Sealants (Floseal®) on Postoperative Spinal Epidural Hematoma during Single-Level Lumbar Decompression Using Biportal Endoscopic Spine Surgery: Clinical and Magnetic Resonance Image Study.BioMed research international · 2020Article
- Prospective application of stem cells to prevent post-operative skeletal fibrosis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2019Review
- Impact of sorafenib on epidural fibrosis: An immunohistochemical study.World journal of clinical cases · 2018Article
- Salvianolic acid B reduced the formation of epidural fibrosis in an experimental rat model.Journal of orthopaedic surgery and research · 2016Article
- An experimental novel study: hyperbaric oxygen treatment on reduction of epidural fibrosis via down-regulation of collagen deposition, IL-6, and TGF-β1.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2015Article
- CCN5 attenuates profibrotic phenotypes of fibroblasts through the Smad6-CCN2 pathway: Potential role in epidural fibrosis.International journal of molecular medicine · 2015Article
- Immunomodulatory effectiveness of licofelone in preventing epidural fibrosis in post-laminectomy rat.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2015Article
- All-trans retinoic Acid reduces joint adhesion formation: an experimental study in rats.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Effects of rapamycin on reduction of peridural fibrosis: an experimental study.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Anti-osteoporotic effects of Angelica sinensis (Oliv.) Diels extract on ovariectomized rats and its oral toxicity in rats.Nutrients · 2014Article
- Study on salvianolic acid B in the reduction of epidural fibrosis in laminectomy rats.BMC musculoskeletal disorders · 2014Article
- Calcium channel blockers in reduction of epidural fibrosis and dural adhesions in laminectomy rats.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2014Article
- The optimal concentration of topical hydroxycamptothecin in preventing intraarticular scar adhesion.Scientific reports · 2014Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With laminectomy being widely accepted as the treatment for lumbar disorders, epidural fibrosis (EF) is a common complication for both the patients and the surgeons alike. Currently, EF is thought to cause recurrent postoperative pain after laminectomy or after discectomy. Angelica sinensis is a traditional Chinese medicine which has shown anti-inflammatory, antifibrotic, and antiproliferative properties. The object of this study was to investigate the effects of Angelica sinensis on the prevention of post-laminectomy EF formation in a rat model. A controlled double-blinded study was conducted in sixty healthy adult Wistar rats that underwent laminectomy at the L1-L2 levels. They were divided randomly into 3 groups according to the treatment method, with 20 in each group: (1) Angelica sinensis treatment group, (2) saline treatment group, and (3) sham group (laminectomy without treatment). All rats were euthanized humanely 4 weeks after laminectomy. The hydroxyproline content, Rydell score, vimentin cells density, fibroblasts density, inflammatory cells density, and inflammatory factors expressions all suggested better results in Angelica sinensis group than the other two groups. Topical application of Angelica sinensis could inhibit fibroblasts proliferation and TGF- β 1 and IL-6 expressions and prevent epidural scar adhesion in postlaminectomy rat model.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.